Numerical modeling of microvascular hemodynamics in plasmodium falciparum malaria

Y. Imai; K. Nakaaki; H. Kondo; T. Ishikawa; C. T. Lim; T. Yamaguchi

doi:10.1007/978-3-642-14515-5_291

Numerical modeling of microvascular hemodynamics in plasmodium falciparum malaria

Y. Imai, K. Nakaaki, H. Kondo, T. Ishikawa, C. T. Lim, T. Yamaguchi

MEN - Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

High concentrations of nitric oxide (NO) have previously been measured in human maxillary sinuses, but the transport rates between the sinus and the nose during normal breathing have not been quantified. In this study, NO transport has been investigated using published NO concentrations and production rates, computational fluid dynamics (CFD) and first-order modeling in stylised physiological, pathological and post-surgical geometries. The results indicate that physiological sinus geometries cannot supply all the NO found in the nasal cavity. Pathological and post-surgical geometries have higher NO transport and lower steady-state NO concentrations than physiological geometries, but no difference was found between the two surgical techniques considered (inferior and middle meatal antrostomy). All the steady state concentrations are also above the level required for bacteriostatic effects.

Original language	English
Title of host publication	6th World Congress of Biomechanics, WCB 2010 - In Conjunction with 14th International Conference on Biomedical Engineering, ICBME and 5th Asia Pacific Conference on Biomechanics, APBiomech
Pages	1145-1148
Number of pages	4
DOIs	https://doi.org/10.1007/978-3-642-14515-5_291
Publication status	Published - 2010
Event	6th World Congress of Biomechanics, WCB 2010 - In Conjunction with 14th International Conference on Biomedical Engineering, ICBME and 5th Asia Pacific Conference on Biomechanics, APBiomech - Singapore, Singapore Duration: 2010 Aug 1 → 2010 Aug 6

Publication series

Name	IFMBE Proceedings
Volume	31 IFMBE
ISSN (Print)	1680-0737

Conference

Conference	6th World Congress of Biomechanics, WCB 2010 - In Conjunction with 14th International Conference on Biomedical Engineering, ICBME and 5th Asia Pacific Conference on Biomechanics, APBiomech
Country/Territory	Singapore
City	Singapore
Period	10/8/1 → 10/8/6

Keywords

Adhesion
Computational mechanics
Malaria
Particle method
Red blood cell

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-3-642-14515-5_291

Cite this

Imai, Y., Nakaaki, K., Kondo, H., Ishikawa, T., Lim, C. T., & Yamaguchi, T. (2010). Numerical modeling of microvascular hemodynamics in plasmodium falciparum malaria. In 6th World Congress of Biomechanics, WCB 2010 - In Conjunction with 14th International Conference on Biomedical Engineering, ICBME and 5th Asia Pacific Conference on Biomechanics, APBiomech (pp. 1145-1148). (IFMBE Proceedings; Vol. 31 IFMBE). https://doi.org/10.1007/978-3-642-14515-5_291

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title = "Numerical modeling of microvascular hemodynamics in plasmodium falciparum malaria",

abstract = "High concentrations of nitric oxide (NO) have previously been measured in human maxillary sinuses, but the transport rates between the sinus and the nose during normal breathing have not been quantified. In this study, NO transport has been investigated using published NO concentrations and production rates, computational fluid dynamics (CFD) and first-order modeling in stylised physiological, pathological and post-surgical geometries. The results indicate that physiological sinus geometries cannot supply all the NO found in the nasal cavity. Pathological and post-surgical geometries have higher NO transport and lower steady-state NO concentrations than physiological geometries, but no difference was found between the two surgical techniques considered (inferior and middle meatal antrostomy). All the steady state concentrations are also above the level required for bacteriostatic effects.",

keywords = "Adhesion, Computational mechanics, Malaria, Particle method, Red blood cell",

author = "Y. Imai and K. Nakaaki and H. Kondo and T. Ishikawa and Lim, {C. T.} and T. Yamaguchi",

year = "2010",

doi = "10.1007/978-3-642-14515-5_291",

language = "English",

isbn = "9783540790389",

series = "IFMBE Proceedings",

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booktitle = "6th World Congress of Biomechanics, WCB 2010 - In Conjunction with 14th International Conference on Biomedical Engineering, ICBME and 5th Asia Pacific Conference on Biomechanics, APBiomech",

note = "6th World Congress of Biomechanics, WCB 2010 - In Conjunction with 14th International Conference on Biomedical Engineering, ICBME and 5th Asia Pacific Conference on Biomechanics, APBiomech ; Conference date: 01-08-2010 Through 06-08-2010",

}

Imai, Y, Nakaaki, K, Kondo, H, Ishikawa, T, Lim, CT & Yamaguchi, T 2010, Numerical modeling of microvascular hemodynamics in plasmodium falciparum malaria. in 6th World Congress of Biomechanics, WCB 2010 - In Conjunction with 14th International Conference on Biomedical Engineering, ICBME and 5th Asia Pacific Conference on Biomechanics, APBiomech. IFMBE Proceedings, vol. 31 IFMBE, pp. 1145-1148, 6th World Congress of Biomechanics, WCB 2010 - In Conjunction with 14th International Conference on Biomedical Engineering, ICBME and 5th Asia Pacific Conference on Biomechanics, APBiomech, Singapore, Singapore, 10/8/1. https://doi.org/10.1007/978-3-642-14515-5_291

Numerical modeling of microvascular hemodynamics in plasmodium falciparum malaria. / Imai, Y.; Nakaaki, K.; Kondo, H. et al.
6th World Congress of Biomechanics, WCB 2010 - In Conjunction with 14th International Conference on Biomedical Engineering, ICBME and 5th Asia Pacific Conference on Biomechanics, APBiomech. 2010. p. 1145-1148 (IFMBE Proceedings; Vol. 31 IFMBE).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Numerical modeling of microvascular hemodynamics in plasmodium falciparum malaria

AU - Imai, Y.

AU - Nakaaki, K.

AU - Kondo, H.

AU - Ishikawa, T.

AU - Lim, C. T.

AU - Yamaguchi, T.

PY - 2010

Y1 - 2010

N2 - High concentrations of nitric oxide (NO) have previously been measured in human maxillary sinuses, but the transport rates between the sinus and the nose during normal breathing have not been quantified. In this study, NO transport has been investigated using published NO concentrations and production rates, computational fluid dynamics (CFD) and first-order modeling in stylised physiological, pathological and post-surgical geometries. The results indicate that physiological sinus geometries cannot supply all the NO found in the nasal cavity. Pathological and post-surgical geometries have higher NO transport and lower steady-state NO concentrations than physiological geometries, but no difference was found between the two surgical techniques considered (inferior and middle meatal antrostomy). All the steady state concentrations are also above the level required for bacteriostatic effects.

AB - High concentrations of nitric oxide (NO) have previously been measured in human maxillary sinuses, but the transport rates between the sinus and the nose during normal breathing have not been quantified. In this study, NO transport has been investigated using published NO concentrations and production rates, computational fluid dynamics (CFD) and first-order modeling in stylised physiological, pathological and post-surgical geometries. The results indicate that physiological sinus geometries cannot supply all the NO found in the nasal cavity. Pathological and post-surgical geometries have higher NO transport and lower steady-state NO concentrations than physiological geometries, but no difference was found between the two surgical techniques considered (inferior and middle meatal antrostomy). All the steady state concentrations are also above the level required for bacteriostatic effects.

KW - Adhesion

KW - Computational mechanics

KW - Malaria

KW - Particle method

KW - Red blood cell

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T3 - IFMBE Proceedings

SP - 1145

EP - 1148

BT - 6th World Congress of Biomechanics, WCB 2010 - In Conjunction with 14th International Conference on Biomedical Engineering, ICBME and 5th Asia Pacific Conference on Biomechanics, APBiomech

T2 - 6th World Congress of Biomechanics, WCB 2010 - In Conjunction with 14th International Conference on Biomedical Engineering, ICBME and 5th Asia Pacific Conference on Biomechanics, APBiomech

Y2 - 1 August 2010 through 6 August 2010

ER -

Imai Y, Nakaaki K, Kondo H, Ishikawa T, Lim CT, Yamaguchi T. Numerical modeling of microvascular hemodynamics in plasmodium falciparum malaria. In 6th World Congress of Biomechanics, WCB 2010 - In Conjunction with 14th International Conference on Biomedical Engineering, ICBME and 5th Asia Pacific Conference on Biomechanics, APBiomech. 2010. p. 1145-1148. (IFMBE Proceedings). doi: 10.1007/978-3-642-14515-5_291

Numerical modeling of microvascular hemodynamics in plasmodium falciparum malaria

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Keywords

UN SDGs

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