TY - GEN
T1 - Observation of transformation behavior of octacalcium phosphate to hydroxyapatite
AU - Ito, Natsuko
AU - Kamitakahara, Masanobu
AU - Ioku, Koji
PY - 2013
Y1 - 2013
N2 - Octacalcium phosphate (OCP) is regarded as a precursor of hydroxyapatite (HA) which is a main inorganic comstituent of human bones and teeth. OCP is becoming regarded as an important biomaterial. Recently, implanted OCP was found to be converted to apatitic phase in the body and support bone regeneration. Therefore, it is important to reveal the transformation mechanism of OCP to HA for revealing the mechanism of bone formation and for the development of biomedical materials for bone. In this study, we focused on the dissolution of OCP and precipitation of HA. OCP particles were immersed in distilled water at 60 ?C. The temporal change of the immersed powders and immersing solution were examined, and the transformation mechanism of OCP to HA was discussed. As there was an unreactive period in the first stage of the transformation, HA crystals seemed to grow easily once HA nuclei were formed. It is speculated that HA nuclei formed on OCP crystals by heterogeneous nucleation, and then HA crystals grow using calcium and phosphoric ions supplied from dissolved OCP.
AB - Octacalcium phosphate (OCP) is regarded as a precursor of hydroxyapatite (HA) which is a main inorganic comstituent of human bones and teeth. OCP is becoming regarded as an important biomaterial. Recently, implanted OCP was found to be converted to apatitic phase in the body and support bone regeneration. Therefore, it is important to reveal the transformation mechanism of OCP to HA for revealing the mechanism of bone formation and for the development of biomedical materials for bone. In this study, we focused on the dissolution of OCP and precipitation of HA. OCP particles were immersed in distilled water at 60 ?C. The temporal change of the immersed powders and immersing solution were examined, and the transformation mechanism of OCP to HA was discussed. As there was an unreactive period in the first stage of the transformation, HA crystals seemed to grow easily once HA nuclei were formed. It is speculated that HA nuclei formed on OCP crystals by heterogeneous nucleation, and then HA crystals grow using calcium and phosphoric ions supplied from dissolved OCP.
KW - Hydroxyapatite
KW - Octacalcium phosphate
KW - Transformation
UR - http://www.scopus.com/inward/record.url?scp=84871285417&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84871285417&partnerID=8YFLogxK
U2 - 10.4028/www.scientific.net/KEM.529-530.11
DO - 10.4028/www.scientific.net/KEM.529-530.11
M3 - Conference contribution
AN - SCOPUS:84871285417
SN - 9783037855171
T3 - Key Engineering Materials
SP - 11
EP - 14
BT - Bioceramics 24
PB - Trans Tech Publications Ltd
T2 - 24th Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2012
Y2 - 21 October 2012 through 24 October 2012
ER -