TY - JOUR
T1 - Octacalcium phosphate (OCP) collagen composites enhance bone healing in a dog tooth extraction socket model
AU - Iibuchi, S.
AU - Matsui, K.
AU - Kawai, T.
AU - Sasaki, K.
AU - Suzuki, O.
AU - Kamakura, S.
AU - Echigo, S.
N1 - Funding Information:
Although this study was supported in part by grants-in aid (17076001, 19390490, 20300165) from the Ministry of Education, Science, Sports and Culture of Japan, and grants from the Japan Science and Technology Agency, Mitsui Sumitomo Insurance Welfare Foundation, and Daiwa Securities Health Foundation, these study sponsors had no involvement in the study design, in the collection, analysis and interpretation of data; in the writing of the manuscript; and in the decision to submit the manuscript for publication.
PY - 2010/2
Y1 - 2010/2
N2 - The authors have reported that a scaffold constructed of synthetic octacalcium phosphate (OCP) and porcine atelocollagen sponge (OCP/Col) enhanced bone regeneration more than sintered β-tricalcium phosphate collagen composite or sintered hydroxyapatite collagen composite with a rat calvarial defect model. To aim for clinical application, the present study investigated whether OCP/Col would enhance bone healing in a dog tooth extraction socket model. Six adult, male, beagle dogs were used. The tooth extraction socket model was made by extracting bilateral third maxillary incisors and the subsequent removal of buccal bone. Disks of OCP/Col were implanted into one side of the model and the other side was untreated. The specimens were fixed 1 or 3 months after implantation. In radiographic analysis, the OCP/Col-treated group showed a wider range of radiopacity than the untreated control. Histologically, the OCP/Col-treated group showed more abundant newly formed bone than untreated control, and the implanted OCP was gradually resorbed. In morphometrical analysis, enlargement of the buccal alveolus in the OCP/Col group was significantly greater than in the untreated control. This study showed that implanted OCP/Col would be replaced by newly formed bone and OCP/Col implantation would enhance bone healing in a tooth socket model.
AB - The authors have reported that a scaffold constructed of synthetic octacalcium phosphate (OCP) and porcine atelocollagen sponge (OCP/Col) enhanced bone regeneration more than sintered β-tricalcium phosphate collagen composite or sintered hydroxyapatite collagen composite with a rat calvarial defect model. To aim for clinical application, the present study investigated whether OCP/Col would enhance bone healing in a dog tooth extraction socket model. Six adult, male, beagle dogs were used. The tooth extraction socket model was made by extracting bilateral third maxillary incisors and the subsequent removal of buccal bone. Disks of OCP/Col were implanted into one side of the model and the other side was untreated. The specimens were fixed 1 or 3 months after implantation. In radiographic analysis, the OCP/Col-treated group showed a wider range of radiopacity than the untreated control. Histologically, the OCP/Col-treated group showed more abundant newly formed bone than untreated control, and the implanted OCP was gradually resorbed. In morphometrical analysis, enlargement of the buccal alveolus in the OCP/Col group was significantly greater than in the untreated control. This study showed that implanted OCP/Col would be replaced by newly formed bone and OCP/Col implantation would enhance bone healing in a tooth socket model.
KW - bone regeneration
KW - collagen
KW - dog
KW - extraction socket
KW - octacalcium phosphate
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UR - http://www.scopus.com/inward/citedby.url?scp=76349096008&partnerID=8YFLogxK
U2 - 10.1016/j.ijom.2009.12.006
DO - 10.1016/j.ijom.2009.12.006
M3 - Article
C2 - 20060266
AN - SCOPUS:76349096008
SN - 0901-5027
VL - 39
SP - 161
EP - 168
JO - International Journal of Oral and Maxillofacial Surgery
JF - International Journal of Oral and Maxillofacial Surgery
IS - 2
ER -