Omission of serial arterial blood sampling for quantitative analysis of monkey PET data using independent component analysis-based method

Mika Naganawa; Hideo Tsukada; Hiroyuki Ohba; Kiichi Ishiwata; Chie Seki; Miho Shidahara; Yuichi Kimura

doi:10.1109/NSSMIC.2007.4437112

Omission of serial arterial blood sampling for quantitative analysis of monkey PET data using independent component analysis-based method

Mika Naganawa, Hideo Tsukada, Hiroyuki Ohba, Kiichi Ishiwata, Chie Seki, Miho Shidahara, Yuichi Kimura

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Citations (Scopus)

Abstract

Serial arterial blood sampling is required to measure a blood input function in quantitative estimation of physiological parameters in dynamic positron emission tomography (PET) studies. However, blood sampling is problematic for animal PET study due to limited amount of blood allowed. Therefore, it is of interest to obviate arterial blood sampling. We have previously proposed a method for estimating a blood input curve based on independent component analysis in human study. In this paper, we applied the method to monkey [¹⁸F]fluorodeoxyglucose studies, and validated its applicability by comparing the estimated regional cerebral metabolic rates of glucose using the estimated and the measured blood input function. Experimental results suggest that the proposed method enables quantitative analysis in PET without serial arterial blood sampling not only in human data but also in monkey data.

Original language	English
Title of host publication	2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC
Pages	4510-4512
Number of pages	3
DOIs	https://doi.org/10.1109/NSSMIC.2007.4437112
Publication status	Published - 2007
Externally published	Yes
Event	2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC - Honolulu, HI, United States Duration: 2007 Oct 27 → 2007 Nov 3

Publication series

Name	IEEE Nuclear Science Symposium Conference Record
Volume	6
ISSN (Print)	1095-7863

Other

Other	2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC
Country/Territory	United States
City	Honolulu, HI
Period	07/10/27 → 07/11/3

ASJC Scopus subject areas

Radiation
Nuclear and High Energy Physics
Radiology Nuclear Medicine and imaging

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10.1109/NSSMIC.2007.4437112

Cite this

Naganawa, M., Tsukada, H., Ohba, H., Ishiwata, K., Seki, C., Shidahara, M., & Kimura, Y. (2007). Omission of serial arterial blood sampling for quantitative analysis of monkey PET data using independent component analysis-based method. In 2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC (pp. 4510-4512). [4437112] (IEEE Nuclear Science Symposium Conference Record; Vol. 6). https://doi.org/10.1109/NSSMIC.2007.4437112

Omission of serial arterial blood sampling for quantitative analysis of monkey PET data using independent component analysis-based method. / Naganawa, Mika; Tsukada, Hideo; Ohba, Hiroyuki et al.

2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC. 2007. p. 4510-4512 4437112 (IEEE Nuclear Science Symposium Conference Record; Vol. 6).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Naganawa, M, Tsukada, H, Ohba, H, Ishiwata, K, Seki, C, Shidahara, M & Kimura, Y 2007, Omission of serial arterial blood sampling for quantitative analysis of monkey PET data using independent component analysis-based method. in 2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC., 4437112, IEEE Nuclear Science Symposium Conference Record, vol. 6, pp. 4510-4512, 2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC, Honolulu, HI, United States, 07/10/27. https://doi.org/10.1109/NSSMIC.2007.4437112

Naganawa M, Tsukada H, Ohba H, Ishiwata K, Seki C, Shidahara M et al. Omission of serial arterial blood sampling for quantitative analysis of monkey PET data using independent component analysis-based method. In 2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC. 2007. p. 4510-4512. 4437112. (IEEE Nuclear Science Symposium Conference Record). doi: 10.1109/NSSMIC.2007.4437112

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abstract = "Serial arterial blood sampling is required to measure a blood input function in quantitative estimation of physiological parameters in dynamic positron emission tomography (PET) studies. However, blood sampling is problematic for animal PET study due to limited amount of blood allowed. Therefore, it is of interest to obviate arterial blood sampling. We have previously proposed a method for estimating a blood input curve based on independent component analysis in human study. In this paper, we applied the method to monkey [18F]fluorodeoxyglucose studies, and validated its applicability by comparing the estimated regional cerebral metabolic rates of glucose using the estimated and the measured blood input function. Experimental results suggest that the proposed method enables quantitative analysis in PET without serial arterial blood sampling not only in human data but also in monkey data.",

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Omission of serial arterial blood sampling for quantitative analysis of monkey PET data using independent component analysis-based method

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