Oncological properties of intravenous leiomyomatosis: Involvement of mesenchymal tumor stem-like cells

Saya Tamura, Takuma Hayashi, Hideki Tokunaga, Nobuo Yaegashi, Kaoru Abiko, Ikuo Konishi

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Uterine leiomyoma, also known as fibroids, is the most common benign neoplasm of the female genital tract. Leiomyoma is the most common uterine tumor. The leiomyoma subtypes account for approximately 10% of leiomyomas. Intravenous leiomyomatosis, a uterine leiomyoma subtype, is an intravascular growth of benign smooth muscle cells, occasionally with pelvic or extrapelvic extension. Uterine leiomyosarcoma, a malignant tumor, tends to metastasize hematogenously, and distant metastasis to the lungs and liver is common. Therefore, the oncological properties of this intravenous leiomyomatosis resemble those of the malignant tumor uterine leiomyosarcoma. Cancer stem cells migrate to distant organs via intravascular infiltration, leading to micrometastases. We examined the oncological properties of intravenous leiomyomatosis using molecular pathological techniques on tissue excised from patients with uterine leiomyoma. CD44-positive mesenchymal tumor stem-like cells were detected in both patients with intravenous leiomyomatosis and uterine leiomyosarcoma. The oncological properties of intravenous leiomyomatosis were found to be similar to those of uterine leiomyosarcoma. However, in intravenous leiomyomatosis, cyclin E and Ki-67-positive cells were rare and no pathological findings suspecting malignancy were observed. It is expected that establishing a treatment method targeting cancer stem cells will lead to the treatment of malignant tumors with a low risk of recurrence and metastasis.

Original languageEnglish
Pages (from-to)1188-1202
Number of pages15
JournalCurrent Issues in Molecular Biology
Issue number2
Publication statusPublished - 2021 Sept


  • Intravenous leiomyomatosis
  • Leiomyoma
  • Leiomyosarcoma
  • Tumor stem-like cells


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