Water is welcome! Chiral α-substituted β,γ-epoxides have been prepared in good yields and with excellent enantioselectivities in a one-pot synthetic procedure. The key reaction of this process, which involves a series of uninterrupted sequential reactions, is an asymmetric aldol reaction of aqueous chloroacetaldehyde mediated by a diarylprolinol derivative (see scheme).
|Number of pages||4|
|Journal||Angewandte Chemie - International Edition|
|Publication status||Published - 2011 Mar 14|
- aldol reaction
- asymmetric synthesis
- diarylprolinol derivatives
ASJC Scopus subject areas