Optimal Control of the F1-ATPase Molecular Motor

Deepak Gupta, Steven J. Large, Shoichi Toyabe, David A. Sivak

Research output: Contribution to journalArticlepeer-review


F1-ATPase is a rotary molecular motor that in vivo is subject to strong nonequilibrium driving forces. There is great interest in understanding the operational principles governing its high efficiency of free-energy transduction. Here we use a near-equilibrium framework to design a nontrivial control protocol to minimize dissipation in rotating F1to synthesize adenosine triphosphate. We find that the designed protocol requires much less work than a naive (constant-velocity) protocol across a wide range of protocol durations. Our analysis points to a possible mechanism for energetically efficient driving of F1in vivo and provides insight into free-energy transduction for a broader class of biomolecular and synthetic machines.

Original languageEnglish
Pages (from-to)11844-11849
Number of pages6
JournalJournal of Physical Chemistry Letters
Issue number51
Publication statusPublished - 2022 Dec 29

ASJC Scopus subject areas

  • Materials Science(all)
  • Physical and Theoretical Chemistry


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