F1-ATPase is a rotary molecular motor that in vivo is subject to strong nonequilibrium driving forces. There is great interest in understanding the operational principles governing its high efficiency of free-energy transduction. Here we use a near-equilibrium framework to design a nontrivial control protocol to minimize dissipation in rotating F1to synthesize adenosine triphosphate. We find that the designed protocol requires much less work than a naive (constant-velocity) protocol across a wide range of protocol durations. Our analysis points to a possible mechanism for energetically efficient driving of F1in vivo and provides insight into free-energy transduction for a broader class of biomolecular and synthetic machines.
|Number of pages||6|
|Journal||Journal of Physical Chemistry Letters|
|Publication status||Published - 2022 Dec 29|
ASJC Scopus subject areas
- Materials Science(all)
- Physical and Theoretical Chemistry