Organic solvent-free, enantio- and diastereoselective, direct Mannich reaction in the presence of water

Yujiro Hayashi, Tatsuya Urushima, Seiji Aratake, Tsubasa Okano, Kazuki Obi

Research output: Contribution to journalArticlepeer-review

110 Citations (Scopus)

Abstract

An organocatalyst-mediated, asymmetric Mannich reaction in the presence of water without using organic solvents has been developed. A highly reactive siloxytetrazole hybrid catalyst has been developed for the reaction of dimethoxyacetaldehyde, while the sodium salt of siloxyproline is an effective catalyst of α-imino glyoxylate. Excellent enantioselectivity can be realized, and the usage of organic solvents can be reduced compared to the conventional reactions in organic solvents.

Original languageEnglish
Pages (from-to)21-24
Number of pages4
JournalOrganic Letters
Volume10
Issue number1
DOIs
Publication statusPublished - 2008 Jan 3

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