Organocatalytic Nucleophilic Substitution Reaction of gem-Difluoroalkenes with Ketene Silyl Acetals

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Abstract

An organocatalytic nucleophilic substitution reaction of gem-difluoroalkenes with ketene silyl acetals was developed. Phosphazene P4-tBu effectively catalyzed the reaction under mild conditions to provide monofluoroalkenes possessing an alkoxycarbonylmethyl group in high yields with high Z selectivities.

Original languageEnglish
Pages (from-to)2277-2280
Number of pages4
JournalOrganic Letters
Volume21
Issue number7
DOIs
Publication statusPublished - 2019 Apr 5

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