Oseltamivir enhances hippocampal network synchronization

Atsushi Usami, Takuya Sasaki, Nobuhiro Satoh, Takahiro Akiba, Satoshi Yokoshima, Tohru Fukuyama, Kenzo Yamatsugu, Motomu Kanai, Masakatsu Shibasaki, Norio Matsuki, Yuji Ikegaya

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)

Abstract

Oseltamivir, a widely used anti-influenza drug, inhibits virus neuraminidase. A mammalian homologue of this enzyme is expressed in the brain, yet the effect of oseltamivir on central neurons is largely unknown. Patch-clamp recordings ex vivo revealed that oseltamivir enhanced spike synchronization between hippocampal CA3 pyramidal cells. Time-lapse multineuron calcium imaging revealed that oseltamivir and its active metabolite evoked synchronized population bursts that recruited virtually all neurons in the network. This unique, so-far-unknown, event was attenuated by muscarinic receptor antagonist. Thus, oseltamivir is a useful tool for investigating a new aspect of neural circuit operation. Supplementary Fig. and movie: available only at http:/ /dx.doi.org/10.1254/jphs.SC0070467.

Original languageEnglish
Pages (from-to)659-662
Number of pages4
JournalJournal of Pharmacological Sciences
Volume106
Issue number4
DOIs
Publication statusPublished - 2008

Keywords

  • Functional multineuron calcium imaging
  • Network excitability
  • Oseltamivir

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