Osseointegration Enhancement by Zr doping of Co-Cr-Mo Implants Fabricated by Electron Beam Melting

Patrik Stenlund; Shingo Kurosu; Yuichiro Koizumi; Felicia Suska; Hiroaki Matsumoto; Akihiko Chiba; Anders Palmquist

doi:10.1016/j.addma.2015.02.002

Osseointegration Enhancement by Zr doping of Co-Cr-Mo Implants Fabricated by Electron Beam Melting

Patrik Stenlund, Shingo Kurosu, Yuichiro Koizumi, Felicia Suska, Hiroaki Matsumoto, Akihiko Chiba, Anders Palmquist

New Industry Creation Hatchery Center (NICHe)

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

Direct osseous healing to prosthetic components is a prerequisite for the clinical success of uncemented treatment in total hip replacements (THR). The demands imposed on the material properties are constantly being stepped up to withstand the impact of an active lifestyle and ensure lifelong integration. Cobalt-chromium-molybdenum (Co-Cr-Mo) materials are interesting for their excellent mechanical stability, corrosion resistance and possibility to be produced by additive manufacturing into complex designs with modifiable stiffness. The bone response to Co-Cr-Mo is regarded as inferior to that of titanium and are usually cemented in THR. The hypothesis in the present study was that a low amount of Zr in the Co-Cr-Mo alloy would improve the bone response and biomechanical anchorage. The results showed significantly higher implant stability for the Co-Cr-Mo alloy with an addition of 0.04% Zr after eight weeks of healing in rabbits, while no major differences were observed in the amount of bone formed around the implants. Further, bone tissue grew into surface irregularities and in direct contact with the implant surfaces. It is concluded that additively manufactured Co-Cr-Mo alloy implants osseointegrate and that the addition of a low amount of Zr to the bulk Co-Cr-Mo further improves the bone anchorage.

Original language	English
Pages (from-to)	6-15
Number of pages	10
Journal	Additive Manufacturing
Volume	6
DOIs	https://doi.org/10.1016/j.addma.2015.02.002
Publication status	Published - 2015 Apr 1

Keywords

Additive manufacturing
Bone anchorage
Cobalt-chromium-molybdenum alloy
In vivo
Zirconium

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10.1016/j.addma.2015.02.002

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@article{7d4e79f6cefc4cd59235e85d90491bfc,

title = "Osseointegration Enhancement by Zr doping of Co-Cr-Mo Implants Fabricated by Electron Beam Melting",

abstract = "Direct osseous healing to prosthetic components is a prerequisite for the clinical success of uncemented treatment in total hip replacements (THR). The demands imposed on the material properties are constantly being stepped up to withstand the impact of an active lifestyle and ensure lifelong integration. Cobalt-chromium-molybdenum (Co-Cr-Mo) materials are interesting for their excellent mechanical stability, corrosion resistance and possibility to be produced by additive manufacturing into complex designs with modifiable stiffness. The bone response to Co-Cr-Mo is regarded as inferior to that of titanium and are usually cemented in THR. The hypothesis in the present study was that a low amount of Zr in the Co-Cr-Mo alloy would improve the bone response and biomechanical anchorage. The results showed significantly higher implant stability for the Co-Cr-Mo alloy with an addition of 0.04% Zr after eight weeks of healing in rabbits, while no major differences were observed in the amount of bone formed around the implants. Further, bone tissue grew into surface irregularities and in direct contact with the implant surfaces. It is concluded that additively manufactured Co-Cr-Mo alloy implants osseointegrate and that the addition of a low amount of Zr to the bulk Co-Cr-Mo further improves the bone anchorage.",

keywords = "Additive manufacturing, Bone anchorage, Cobalt-chromium-molybdenum alloy, In vivo, Zirconium",

author = "Patrik Stenlund and Shingo Kurosu and Yuichiro Koizumi and Felicia Suska and Hiroaki Matsumoto and Akihiko Chiba and Anders Palmquist",

note = "Funding Information: The authors are indebted to Peter Thomsen and Jukka Lausmaa for their ideas and support and to Lena Emanuelsson, Birgitta Norlindh and Maria Hoffman for excellent technical assistance during surgery and histological preparation. The support of the VINNOVA-JSPS, the Swedish Research Council (Grant K2012-52X-09495-25-3 ), the LUA grant ( ALFGBG-138721 ), the BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy , the Region V{\"a}stra G{\"o}taland , Adlerbertska Foundation , IngaBritt and Arne Lundberg Foundation , Promobilia and the Hjalmar Svensson Foundation is gratefully acknowledged. This research was partly supported by the Regional Innovation Cluster Program 2010, a grant-in-aid for Scientific Research Development, the Cooperation of Innovative Technology and Advanced Research in Evolving Area from MEXT and a grant-in-aid from the JSPS . Publisher Copyright: {\textcopyright} 2015 Published by Elsevier B.V.",

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doi = "10.1016/j.addma.2015.02.002",

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T1 - Osseointegration Enhancement by Zr doping of Co-Cr-Mo Implants Fabricated by Electron Beam Melting

AU - Stenlund, Patrik

AU - Kurosu, Shingo

AU - Koizumi, Yuichiro

AU - Suska, Felicia

AU - Matsumoto, Hiroaki

AU - Chiba, Akihiko

AU - Palmquist, Anders

N1 - Funding Information: The authors are indebted to Peter Thomsen and Jukka Lausmaa for their ideas and support and to Lena Emanuelsson, Birgitta Norlindh and Maria Hoffman for excellent technical assistance during surgery and histological preparation. The support of the VINNOVA-JSPS, the Swedish Research Council (Grant K2012-52X-09495-25-3 ), the LUA grant ( ALFGBG-138721 ), the BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy , the Region Västra Götaland , Adlerbertska Foundation , IngaBritt and Arne Lundberg Foundation , Promobilia and the Hjalmar Svensson Foundation is gratefully acknowledged. This research was partly supported by the Regional Innovation Cluster Program 2010, a grant-in-aid for Scientific Research Development, the Cooperation of Innovative Technology and Advanced Research in Evolving Area from MEXT and a grant-in-aid from the JSPS . Publisher Copyright: © 2015 Published by Elsevier B.V.

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Direct osseous healing to prosthetic components is a prerequisite for the clinical success of uncemented treatment in total hip replacements (THR). The demands imposed on the material properties are constantly being stepped up to withstand the impact of an active lifestyle and ensure lifelong integration. Cobalt-chromium-molybdenum (Co-Cr-Mo) materials are interesting for their excellent mechanical stability, corrosion resistance and possibility to be produced by additive manufacturing into complex designs with modifiable stiffness. The bone response to Co-Cr-Mo is regarded as inferior to that of titanium and are usually cemented in THR. The hypothesis in the present study was that a low amount of Zr in the Co-Cr-Mo alloy would improve the bone response and biomechanical anchorage. The results showed significantly higher implant stability for the Co-Cr-Mo alloy with an addition of 0.04% Zr after eight weeks of healing in rabbits, while no major differences were observed in the amount of bone formed around the implants. Further, bone tissue grew into surface irregularities and in direct contact with the implant surfaces. It is concluded that additively manufactured Co-Cr-Mo alloy implants osseointegrate and that the addition of a low amount of Zr to the bulk Co-Cr-Mo further improves the bone anchorage.

AB - Direct osseous healing to prosthetic components is a prerequisite for the clinical success of uncemented treatment in total hip replacements (THR). The demands imposed on the material properties are constantly being stepped up to withstand the impact of an active lifestyle and ensure lifelong integration. Cobalt-chromium-molybdenum (Co-Cr-Mo) materials are interesting for their excellent mechanical stability, corrosion resistance and possibility to be produced by additive manufacturing into complex designs with modifiable stiffness. The bone response to Co-Cr-Mo is regarded as inferior to that of titanium and are usually cemented in THR. The hypothesis in the present study was that a low amount of Zr in the Co-Cr-Mo alloy would improve the bone response and biomechanical anchorage. The results showed significantly higher implant stability for the Co-Cr-Mo alloy with an addition of 0.04% Zr after eight weeks of healing in rabbits, while no major differences were observed in the amount of bone formed around the implants. Further, bone tissue grew into surface irregularities and in direct contact with the implant surfaces. It is concluded that additively manufactured Co-Cr-Mo alloy implants osseointegrate and that the addition of a low amount of Zr to the bulk Co-Cr-Mo further improves the bone anchorage.

KW - Additive manufacturing

KW - Bone anchorage

KW - Cobalt-chromium-molybdenum alloy

KW - In vivo

KW - Zirconium

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ER -

Osseointegration Enhancement by Zr doping of Co-Cr-Mo Implants Fabricated by Electron Beam Melting

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Keywords

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