TY - JOUR
T1 - Outcomes of lung transplantation for idiopathic pleuroparenchymal fibroelastosis
AU - Shiiya, Haruhiko
AU - Nakajima, Jun
AU - Date, Hiroshi
AU - Chen-Yoshikawa, Toyofumi Fengshi
AU - Tanizawa, Kiminobu
AU - Handa, Tomohiro
AU - Oto, Takahiro
AU - Otani, Shinji
AU - Shiotani, Toshio
AU - Okada, Yoshinori
AU - Matsuda, Yasushi
AU - Shiraishi, Takeshi
AU - Moroga, Toshihiko
AU - Minami, Masato
AU - Funaki, Soichiro
AU - Chida, Masayuki
AU - Yoshino, Ichiro
AU - Hatachi, Go
AU - Uemura, Yukari
AU - Sato, Masaaki
N1 - Funding Information:
We thank the Japanese Society of Lung and Heart-Lung Transplantation for helping us to collect the patients’ data.
Publisher Copyright:
© 2021, Springer Nature Singapore Pte Ltd.
PY - 2021/8
Y1 - 2021/8
N2 - Purpose: This study was performed to compare the outcome of lung transplantation (LT) for idiopathic pleuroparenchymal fibroelastosis (IPPFE) with that of LT for idiopathic pulmonary fibrosis (IPF). Methods: We reviewed, retrospectively, all adult patients who underwent LT for IPPFE or IPF in Japan between 1998 and 2018. Results: There were 100 patients eligible for this study (31 with IPPFE and 69 with IPF). Patients with IPPFE tended to have a significantly lower body mass index (BMI) than those with IPF (median, 16.7 vs. 22.6 kg/m2, respectively; P < 0.01). However, Kaplan–Meier survival curves showed no significant difference in overall survival between the groups. The BMI did not increase in patients with IPPFE, even 1 year after LT (pretransplant, 16.5 ± 3.2 kg/m2 vs. 1 year post-transplant, 15.6 ± 2.5 kg/m2; P = 0.08). The percent predicted forced vital capacity (%FVC) 1 year after LT was significantly lower in the IPPFE group than in the IPF group (48.4% ± 19.5% vs. 68.6% ± 15.5%, respectively; P < 0.01). Conclusions: Despite extrapulmonary problems such as a flat chest, low BMI, and associated restrictive impairment persisting in patients with IPPFE, patient survival after LT for IPPFE or IPF was equivalent.
AB - Purpose: This study was performed to compare the outcome of lung transplantation (LT) for idiopathic pleuroparenchymal fibroelastosis (IPPFE) with that of LT for idiopathic pulmonary fibrosis (IPF). Methods: We reviewed, retrospectively, all adult patients who underwent LT for IPPFE or IPF in Japan between 1998 and 2018. Results: There were 100 patients eligible for this study (31 with IPPFE and 69 with IPF). Patients with IPPFE tended to have a significantly lower body mass index (BMI) than those with IPF (median, 16.7 vs. 22.6 kg/m2, respectively; P < 0.01). However, Kaplan–Meier survival curves showed no significant difference in overall survival between the groups. The BMI did not increase in patients with IPPFE, even 1 year after LT (pretransplant, 16.5 ± 3.2 kg/m2 vs. 1 year post-transplant, 15.6 ± 2.5 kg/m2; P = 0.08). The percent predicted forced vital capacity (%FVC) 1 year after LT was significantly lower in the IPPFE group than in the IPF group (48.4% ± 19.5% vs. 68.6% ± 15.5%, respectively; P < 0.01). Conclusions: Despite extrapulmonary problems such as a flat chest, low BMI, and associated restrictive impairment persisting in patients with IPPFE, patient survival after LT for IPPFE or IPF was equivalent.
KW - Chest wall
KW - Interstitial lung disease
KW - Lung
KW - Pulmonary function
KW - Survival analysis
KW - Transplantation
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U2 - 10.1007/s00595-021-02232-6
DO - 10.1007/s00595-021-02232-6
M3 - Article
C2 - 33576927
AN - SCOPUS:85100991100
SN - 0941-1291
VL - 51
SP - 1276
EP - 1284
JO - Surgery Today
JF - Surgery Today
IS - 8
ER -