Over-expression of Flt3 induces NF-κB pathway and increases the expression of IL-6

Shinichiro Takahashi, Hideo Harigae, Keiko Kumura Ishii, Mitsue Inomata, Tohru Fujiwara, Hisayuki Yokoyama, Kenichi Ishizawa, Junichi Kameoka, Jonathan D. Licht, Takeshi Sasaki, Mitsuo Kaku

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)


Activating mutations or over-expression of the Flt3 is prevalent in acute myeloblastic leukemia (AML), associated with activation of Ras/MAP kinase and other signaling pathways. In this study, we addressed the role of Flt3 in the activation of nuclear factor-kappa B (NF-κB), which is a target molecule of these kinase pathways. In BaF3 cells stably expressing Flt3, a NF-κB-responsive reporter was upregulated and its target gene, IL-6, was increased by the involvement of Flt3-ERK/MAPK-NF-κB pathway. Furthermore, we found a modest positive correlation (r = 0.35, p = 0.096) between Flt3 and IL-6 mRNA expression in 24 AML specimens. These results suggest a role of Flt3 over-expression in NF-κB pathway.

Original languageEnglish
Pages (from-to)893-899
Number of pages7
JournalLeukemia Research
Issue number8
Publication statusPublished - 2005 Aug


  • AML
  • Flt3
  • IL-6
  • NF-κB

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research


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