Oxidized LDL and expression of monocyte adhesion molecules

Toru Kita; Noriaki Kume; Kenji Ishii; Hisanori Horiuchi; Hidenori Arai; Masayuki Yokode

doi:10.1016/S0168-8227(99)00041-8

Oxidized LDL and expression of monocyte adhesion molecules

Toru Kita, Noriaki Kume, Kenji Ishii, Hisanori Horiuchi, Hidenori Arai, Masayuki Yokode

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Accumulation of substantial numbers of monocyte/macrophages, as well as activated T lymphocytes, in focal areas of arterial intima appears to be a hallmark of atherogenesis. Our report demonstrated that lysophosphatidylcholine (lyso-PC), a polar phospholipid component that is increased in atherogenic lipoproteins, such as oxidized LDL and remnants lipoproteins in diabetic and type III hyperlipidemic patients, can upregulate adhesion molecules for monocytes and T lymphocytes, and growth factors, such as heparin-binding epidermal growth factor-like growth factor and PDGF-A and B chains. Recently we identified the novel receptor for oxidized LDL, named Lox-1. Therefore in this paper we summarize the importance of the interaction between oxidized LDL and its receptor, LOX-1 in terms of early stage of atherogenesis.

Original language	English
Pages (from-to)	123-126
Number of pages	4
Journal	Diabetes Research and Clinical Practice
Volume	45
Issue number	2-3
DOIs	https://doi.org/10.1016/S0168-8227(99)00041-8
Publication status	Published - 1999 Sept
Externally published	Yes

Keywords

Lox-1
Lysophosphatidylcholine
Monocyte adhesion molecules
Oxidized LDL

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/S0168-8227(99)00041-8

Cite this

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title = "Oxidized LDL and expression of monocyte adhesion molecules",

abstract = "Accumulation of substantial numbers of monocyte/macrophages, as well as activated T lymphocytes, in focal areas of arterial intima appears to be a hallmark of atherogenesis. Our report demonstrated that lysophosphatidylcholine (lyso-PC), a polar phospholipid component that is increased in atherogenic lipoproteins, such as oxidized LDL and remnants lipoproteins in diabetic and type III hyperlipidemic patients, can upregulate adhesion molecules for monocytes and T lymphocytes, and growth factors, such as heparin-binding epidermal growth factor-like growth factor and PDGF-A and B chains. Recently we identified the novel receptor for oxidized LDL, named Lox-1. Therefore in this paper we summarize the importance of the interaction between oxidized LDL and its receptor, LOX-1 in terms of early stage of atherogenesis.",

keywords = "Lox-1, Lysophosphatidylcholine, Monocyte adhesion molecules, Oxidized LDL",

author = "Toru Kita and Noriaki Kume and Kenji Ishii and Hisanori Horiuchi and Hidenori Arai and Masayuki Yokode",

year = "1999",

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doi = "10.1016/S0168-8227(99)00041-8",

language = "English",

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journal = "Diabetes Research and Clinical Practice",

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T1 - Oxidized LDL and expression of monocyte adhesion molecules

AU - Kita, Toru

AU - Kume, Noriaki

AU - Ishii, Kenji

AU - Horiuchi, Hisanori

AU - Arai, Hidenori

AU - Yokode, Masayuki

PY - 1999/9

Y1 - 1999/9

N2 - Accumulation of substantial numbers of monocyte/macrophages, as well as activated T lymphocytes, in focal areas of arterial intima appears to be a hallmark of atherogenesis. Our report demonstrated that lysophosphatidylcholine (lyso-PC), a polar phospholipid component that is increased in atherogenic lipoproteins, such as oxidized LDL and remnants lipoproteins in diabetic and type III hyperlipidemic patients, can upregulate adhesion molecules for monocytes and T lymphocytes, and growth factors, such as heparin-binding epidermal growth factor-like growth factor and PDGF-A and B chains. Recently we identified the novel receptor for oxidized LDL, named Lox-1. Therefore in this paper we summarize the importance of the interaction between oxidized LDL and its receptor, LOX-1 in terms of early stage of atherogenesis.

AB - Accumulation of substantial numbers of monocyte/macrophages, as well as activated T lymphocytes, in focal areas of arterial intima appears to be a hallmark of atherogenesis. Our report demonstrated that lysophosphatidylcholine (lyso-PC), a polar phospholipid component that is increased in atherogenic lipoproteins, such as oxidized LDL and remnants lipoproteins in diabetic and type III hyperlipidemic patients, can upregulate adhesion molecules for monocytes and T lymphocytes, and growth factors, such as heparin-binding epidermal growth factor-like growth factor and PDGF-A and B chains. Recently we identified the novel receptor for oxidized LDL, named Lox-1. Therefore in this paper we summarize the importance of the interaction between oxidized LDL and its receptor, LOX-1 in terms of early stage of atherogenesis.

KW - Lox-1

KW - Lysophosphatidylcholine

KW - Monocyte adhesion molecules

KW - Oxidized LDL

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JO - Diabetes Research and Clinical Practice

JF - Diabetes Research and Clinical Practice

IS - 2-3

ER -

Oxidized LDL and expression of monocyte adhesion molecules

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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