Palladium-catalyzed addition of nitrogen pronucleophiles to alkylidenecyclopropanes

Amal I. Siriwardana, Michiru Kamada, Itaru Nakamura, Yoshinori Yamamoto

Research output: Contribution to journalArticlepeer-review

73 Citations (Scopus)


The inter- and intramolecular additions of cyclic amides (nitrogen pronucleophiles) to methylenecyclopropanes proceeded smoothly in the presence of catalytic amounts of Pd(PPh3)4, affording the corresponding hydroamination products in good to high yields with high regioselectivities. The ring opening of methylenecyclopropanes occurred at the distal position of the cyclopropane ring.

Original languageEnglish
Pages (from-to)5932-5937
Number of pages6
JournalJournal of Organic Chemistry
Issue number15
Publication statusPublished - 2005 Jul 22


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