Abstract
The palladium(0)-catalyzed condensation of aryl halides with the sodium salts of phenylsulfonylacetonitrile and diethyl cyanomethylphosphonate in dimethoxyethane gave the corresponding α-phenylsulfonylareneacetonitriles and diethyl arylcyanomethylphosphonates in good yields. The α-phenylsulfonylareneacetonitriles were easily desulfonylated with zinc to give the areneacetonitriles, and the arylcyanomethylphosphonates were converted to the alkylideneareneacetonitriles by means of the Horner-Emmons reaction.
| Original language | English |
|---|---|
| Pages (from-to) | 1513-1517 |
| Number of pages | 5 |
| Journal | Chemical and Pharmaceutical Bulletin |
| Volume | 38 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 1990 |
Keywords
- Horner-Emmons reaction
- aryl halide
- desulfonylation
- diethyl cyanomethylphosphonate
- palladium-catalyzed reaction
- phenylsulfonylacetonitrile
- zinc dust
ASJC Scopus subject areas
- Chemistry(all)
- Drug Discovery