Palladium-catalyzed intramolecular amidation of C(sp2)-H bonds: Synthesis of 4-aryl-2-quinolinones

Kiyofumi Inamoto, Tadataka Saito, Kou Hiroya, Takayuki Doi

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105 Citations (Scopus)


Figure presented A catalytic synthetic approach for the synthesis of 2-quinolinone compounds through a Pd-catalyzed C(sp2)-H functionalization/intramolecular amidation sequence is described. The cyclization process efficiently proceeds in the presence of a catalytic amount of PdCl2 and Cu(OAc)2 under an O2 atmosphere, providing practical access to a range of variously substituted 4-aryl-2-quinolinones.

Original languageEnglish
Pages (from-to)3900-3903
Number of pages4
JournalJournal of Organic Chemistry
Issue number11
Publication statusPublished - 2010 Jun 4


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