Palladium-catalyzed intramolecular amidation of C(sp2)-H bonds: Synthesis of 4-aryl-2-quinolinones

Kiyofumi Inamoto; Tadataka Saito; Kou Hiroya; Takayuki Doi

doi:10.1021/jo100557s

Palladium-catalyzed intramolecular amidation of C(sp²)-H bonds: Synthesis of 4-aryl-2-quinolinones

Kiyofumi Inamoto, Tadataka Saito, Kou Hiroya, Takayuki Doi

PHA - Molecular Pharmaceutical Science

Tohoku University

Research output: Contribution to journal › Article › peer-review

105 Citations (Scopus)

Abstract

Figure presented A catalytic synthetic approach for the synthesis of 2-quinolinone compounds through a Pd-catalyzed C(sp²)-H functionalization/intramolecular amidation sequence is described. The cyclization process efficiently proceeds in the presence of a catalytic amount of PdCl₂ and Cu(OAc)₂ under an O₂ atmosphere, providing practical access to a range of variously substituted 4-aryl-2-quinolinones.

Original language	English
Pages (from-to)	3900-3903
Number of pages	4
Journal	Journal of Organic Chemistry
Volume	75
Issue number	11
DOIs	https://doi.org/10.1021/jo100557s
Publication status	Published - 2010 Jun 4

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abstract = "Figure presented A catalytic synthetic approach for the synthesis of 2-quinolinone compounds through a Pd-catalyzed C(sp2)-H functionalization/intramolecular amidation sequence is described. The cyclization process efficiently proceeds in the presence of a catalytic amount of PdCl2 and Cu(OAc)2 under an O2 atmosphere, providing practical access to a range of variously substituted 4-aryl-2-quinolinones.",

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AU - Hiroya, Kou

AU - Doi, Takayuki

PY - 2010/6/4

Y1 - 2010/6/4

N2 - Figure presented A catalytic synthetic approach for the synthesis of 2-quinolinone compounds through a Pd-catalyzed C(sp2)-H functionalization/intramolecular amidation sequence is described. The cyclization process efficiently proceeds in the presence of a catalytic amount of PdCl2 and Cu(OAc)2 under an O2 atmosphere, providing practical access to a range of variously substituted 4-aryl-2-quinolinones.

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Palladium-catalyzed intramolecular amidation of C(sp²)-H bonds: Synthesis of 4-aryl-2-quinolinones

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