Parallel synthesis of oligosaccharide conjugated enediynes onto silyl-linked solid-support

A. Matsuda; T. Doi; H. Tanaka; T. Takahashi

doi:10.1055/s-2001-15164

Parallel synthesis of oligosaccharide conjugated enediynes onto silyl-linked solid-support

A. Matsuda, T. Doi, H. Tanaka, T. Takahashi

PHA - Molecular Pharmaceutical Science

Tokyo Institute of Technology

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

A solid-phase synthesis of enediyne molecules containing a sugar moiety is reported. Polymer-supported (2-mercaptoethyl)glycosides linked through a trialkylsilane linker were coupled to a bromoacetate on an enediyne by S-alkylation. After simple washing of the polymer, mild acid treatment, and evaporation, the desired oligosaccharide conjugated enediynes were isolated in pure form in parallel fashion.

Original language	English
Pages (from-to)	1101-1104
Number of pages	4
Journal	Synlett
Issue number	7
DOIs	https://doi.org/10.1055/s-2001-15164
Publication status	Published - 2001

Keywords

Coupling
Oligosaccharides
Solid-phase synthesis
Thiols

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10.1055/s-2001-15164

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abstract = "A solid-phase synthesis of enediyne molecules containing a sugar moiety is reported. Polymer-supported (2-mercaptoethyl)glycosides linked through a trialkylsilane linker were coupled to a bromoacetate on an enediyne by S-alkylation. After simple washing of the polymer, mild acid treatment, and evaporation, the desired oligosaccharide conjugated enediynes were isolated in pure form in parallel fashion.",

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AU - Matsuda, A.

AU - Doi, T.

AU - Tanaka, H.

AU - Takahashi, T.

PY - 2001

Y1 - 2001

N2 - A solid-phase synthesis of enediyne molecules containing a sugar moiety is reported. Polymer-supported (2-mercaptoethyl)glycosides linked through a trialkylsilane linker were coupled to a bromoacetate on an enediyne by S-alkylation. After simple washing of the polymer, mild acid treatment, and evaporation, the desired oligosaccharide conjugated enediynes were isolated in pure form in parallel fashion.

AB - A solid-phase synthesis of enediyne molecules containing a sugar moiety is reported. Polymer-supported (2-mercaptoethyl)glycosides linked through a trialkylsilane linker were coupled to a bromoacetate on an enediyne by S-alkylation. After simple washing of the polymer, mild acid treatment, and evaporation, the desired oligosaccharide conjugated enediynes were isolated in pure form in parallel fashion.

KW - Coupling

KW - Oligosaccharides

KW - Solid-phase synthesis

KW - Thiols

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JO - Synlett

JF - Synlett

IS - 7

ER -

Parallel synthesis of oligosaccharide conjugated enediynes onto silyl-linked solid-support

Abstract

Keywords

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