TY - JOUR
T1 - Parametric mapping of blood flow and arterial blood volume in dynamic O-15 water brain PET by cluster analysis
AU - Kim, Kyeong Min
AU - Watabe, Hiroshi
AU - Kudomi, Nobuyuki
AU - Hayashi, Takuya
AU - Hayashida, Kohei
AU - Iida, Hidehiro
PY - 2003
Y1 - 2003
N2 - A method for simultaneous parametric mapping of both cerebral blood flow (CBF) and cerebral blood volume of artery (CBVa) from single dynamic water image is presented. This method incorporates the 2-compartment model including arterial vascular volume (Va), and cluster analysis for suppressing noise in generating parametric image. A dynamic O-15 water PET scan was performed, after a static O-15 CO gas scan. Arterial input function was obtained during the dynamic scan. Using the reconstructed dynamic image, both images of CBF and CBVa were generated by the presented method. Both generated images of CBF and CBVa were compared to those generated by conventional autoradiography (ARG) and CO image. The CBF image by this method showed the elimination of CBVa component, and was comparable with that by ARG, in terms of quantitative CBF value and noise. The CBVa image showed the spatial distribution of activities of pure arterial blood volume only, quantitative value and suppressed noise, in contrast to the image of total blood volume from CO image including artery and vein together. The new method with cluster analysis could create the images with quantitative values of CBF and Va, with improved signal-to-noise ratio. The image of CBVa provided the intuitional information of arterial blood volume only. This method could contribute to improved diagnosis of cerebrovascular disease using O-15 water PET.
AB - A method for simultaneous parametric mapping of both cerebral blood flow (CBF) and cerebral blood volume of artery (CBVa) from single dynamic water image is presented. This method incorporates the 2-compartment model including arterial vascular volume (Va), and cluster analysis for suppressing noise in generating parametric image. A dynamic O-15 water PET scan was performed, after a static O-15 CO gas scan. Arterial input function was obtained during the dynamic scan. Using the reconstructed dynamic image, both images of CBF and CBVa were generated by the presented method. Both generated images of CBF and CBVa were compared to those generated by conventional autoradiography (ARG) and CO image. The CBF image by this method showed the elimination of CBVa component, and was comparable with that by ARG, in terms of quantitative CBF value and noise. The CBVa image showed the spatial distribution of activities of pure arterial blood volume only, quantitative value and suppressed noise, in contrast to the image of total blood volume from CO image including artery and vein together. The new method with cluster analysis could create the images with quantitative values of CBF and Va, with improved signal-to-noise ratio. The image of CBVa provided the intuitional information of arterial blood volume only. This method could contribute to improved diagnosis of cerebrovascular disease using O-15 water PET.
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M3 - Conference article
AN - SCOPUS:11944261246
SN - 1095-7863
VL - 5
SP - 3108
EP - 3109
JO - IEEE Nuclear Science Symposium Conference Record
JF - IEEE Nuclear Science Symposium Conference Record
M1 - M14-237
T2 - 2003 IEEE Nuclear Science Symposium Conference Record - Nuclear Science Symposium, Medical Imaging Conference
Y2 - 19 October 2003 through 25 October 2003
ER -