Particle method for computer simulation of red blood cell motion in blood flow

Ken ichi Tsubota; Shigeo Wada; Takami Yamaguchi

doi:10.1016/j.cmpb.2006.06.005

Particle method for computer simulation of red blood cell motion in blood flow

Ken ichi Tsubota, Shigeo Wada, Takami Yamaguchi

Research output: Contribution to journal › Article › peer-review

111 Citations (Scopus)

Abstract

A particle method for the computer simulation of blood flow was proposed to analyze the motion of a deformable red blood cell (RBC) in flowing blood plasma. The RBC and plasma were discretized by particles that have the characteristics of an elastic membrane and a viscous fluid, respectively. The membrane particles were connected to their neighboring membrane particles by springs, and the motion of the particles was determined on the basis of the minimum energy principle. The incompressible flow of plasma that was expressed by the motion of the fluid particles was determined by the moving-particle semi-implicit (MPS) method. The RBC motion and plasma flow were weakly coupled. The two-dimensional simulation of blood flow between parallel plates demonstrated the capability of the proposed method to express the blood flow phenomena observed in experiments, such as the downstream motion of the RBC and the deformation of the RBC into a parachute shape.

Original language	English
Pages (from-to)	139-146
Number of pages	8
Journal	Computer Methods and Programs in Biomedicine
Volume	83
Issue number	2
DOIs	https://doi.org/10.1016/j.cmpb.2006.06.005
Publication status	Published - 2006 Aug
Externally published	Yes

Keywords

Blood flow
Computational biomechanics
Fluid-solid coupled analysis
Particle method
Plasma flow
Red blood cell

ASJC Scopus subject areas

Software
Computer Science Applications
Health Informatics

Access to Document

10.1016/j.cmpb.2006.06.005

Cite this

@article{cad23f7607a6414781c76e34aa8bada1,

title = "Particle method for computer simulation of red blood cell motion in blood flow",

abstract = "A particle method for the computer simulation of blood flow was proposed to analyze the motion of a deformable red blood cell (RBC) in flowing blood plasma. The RBC and plasma were discretized by particles that have the characteristics of an elastic membrane and a viscous fluid, respectively. The membrane particles were connected to their neighboring membrane particles by springs, and the motion of the particles was determined on the basis of the minimum energy principle. The incompressible flow of plasma that was expressed by the motion of the fluid particles was determined by the moving-particle semi-implicit (MPS) method. The RBC motion and plasma flow were weakly coupled. The two-dimensional simulation of blood flow between parallel plates demonstrated the capability of the proposed method to express the blood flow phenomena observed in experiments, such as the downstream motion of the RBC and the deformation of the RBC into a parachute shape.",

keywords = "Blood flow, Computational biomechanics, Fluid-solid coupled analysis, Particle method, Plasma flow, Red blood cell",

author = "Tsubota, {Ken ichi} and Shigeo Wada and Takami Yamaguchi",

note = "Funding Information: The authors acknowledge Prof. Seiichi Koshizuka at the University of Tokyo for providing the source code for the basic part of the MPS method. They are also grateful to Prof. Ryo Kobayashi at Hiroshima University for helpful comments on the elastic RBC membrane model. This work was financially supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan, a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (JSPS), and “Revolutionary Simulation Software (RSS21)” project supported by next-generation IT program of MEXT.",

year = "2006",

month = aug,

doi = "10.1016/j.cmpb.2006.06.005",

language = "English",

volume = "83",

pages = "139--146",

journal = "Computer Methods and Programs in Biomedicine",

issn = "0169-2607",

publisher = "Elsevier Ireland Ltd",

number = "2",

}

TY - JOUR

T1 - Particle method for computer simulation of red blood cell motion in blood flow

AU - Tsubota, Ken ichi

AU - Wada, Shigeo

AU - Yamaguchi, Takami

N1 - Funding Information: The authors acknowledge Prof. Seiichi Koshizuka at the University of Tokyo for providing the source code for the basic part of the MPS method. They are also grateful to Prof. Ryo Kobayashi at Hiroshima University for helpful comments on the elastic RBC membrane model. This work was financially supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan, a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (JSPS), and “Revolutionary Simulation Software (RSS21)” project supported by next-generation IT program of MEXT.

PY - 2006/8

Y1 - 2006/8

N2 - A particle method for the computer simulation of blood flow was proposed to analyze the motion of a deformable red blood cell (RBC) in flowing blood plasma. The RBC and plasma were discretized by particles that have the characteristics of an elastic membrane and a viscous fluid, respectively. The membrane particles were connected to their neighboring membrane particles by springs, and the motion of the particles was determined on the basis of the minimum energy principle. The incompressible flow of plasma that was expressed by the motion of the fluid particles was determined by the moving-particle semi-implicit (MPS) method. The RBC motion and plasma flow were weakly coupled. The two-dimensional simulation of blood flow between parallel plates demonstrated the capability of the proposed method to express the blood flow phenomena observed in experiments, such as the downstream motion of the RBC and the deformation of the RBC into a parachute shape.

AB - A particle method for the computer simulation of blood flow was proposed to analyze the motion of a deformable red blood cell (RBC) in flowing blood plasma. The RBC and plasma were discretized by particles that have the characteristics of an elastic membrane and a viscous fluid, respectively. The membrane particles were connected to their neighboring membrane particles by springs, and the motion of the particles was determined on the basis of the minimum energy principle. The incompressible flow of plasma that was expressed by the motion of the fluid particles was determined by the moving-particle semi-implicit (MPS) method. The RBC motion and plasma flow were weakly coupled. The two-dimensional simulation of blood flow between parallel plates demonstrated the capability of the proposed method to express the blood flow phenomena observed in experiments, such as the downstream motion of the RBC and the deformation of the RBC into a parachute shape.

KW - Blood flow

KW - Computational biomechanics

KW - Fluid-solid coupled analysis

KW - Particle method

KW - Plasma flow

KW - Red blood cell

UR - http://www.scopus.com/inward/record.url?scp=33746891572&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33746891572&partnerID=8YFLogxK

U2 - 10.1016/j.cmpb.2006.06.005

DO - 10.1016/j.cmpb.2006.06.005

M3 - Article

C2 - 16879895

AN - SCOPUS:33746891572

SN - 0169-2607

VL - 83

SP - 139

EP - 146

JO - Computer Methods and Programs in Biomedicine

JF - Computer Methods and Programs in Biomedicine

IS - 2

ER -

Particle method for computer simulation of red blood cell motion in blood flow

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this