Particle method for computer simulation of red blood cell motion in blood flow

Ken ichi Tsubota, Shigeo Wada, Takami Yamaguchi

Research output: Contribution to journalArticlepeer-review

111 Citations (Scopus)


A particle method for the computer simulation of blood flow was proposed to analyze the motion of a deformable red blood cell (RBC) in flowing blood plasma. The RBC and plasma were discretized by particles that have the characteristics of an elastic membrane and a viscous fluid, respectively. The membrane particles were connected to their neighboring membrane particles by springs, and the motion of the particles was determined on the basis of the minimum energy principle. The incompressible flow of plasma that was expressed by the motion of the fluid particles was determined by the moving-particle semi-implicit (MPS) method. The RBC motion and plasma flow were weakly coupled. The two-dimensional simulation of blood flow between parallel plates demonstrated the capability of the proposed method to express the blood flow phenomena observed in experiments, such as the downstream motion of the RBC and the deformation of the RBC into a parachute shape.

Original languageEnglish
Pages (from-to)139-146
Number of pages8
JournalComputer Methods and Programs in Biomedicine
Issue number2
Publication statusPublished - 2006 Aug
Externally publishedYes


  • Blood flow
  • Computational biomechanics
  • Fluid-solid coupled analysis
  • Particle method
  • Plasma flow
  • Red blood cell

ASJC Scopus subject areas

  • Software
  • Computer Science Applications
  • Health Informatics


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