Particle method simulation of red blood cells infected by malaria

Takami Yamaguchi; Young Ho Kang; Hitoshi Kondo; Yohsuke Imai; Takuji Ishikawa

doi:10.1007/978-3-642-03882-2_104

Particle method simulation of red blood cells infected by malaria

Takami Yamaguchi, Young Ho Kang, Hitoshi Kondo, Yohsuke Imai, Takuji Ishikawa

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

When a malaria parasite invades and matures inside a red blood cell (RBC), the infected RBC (IRBC) becomes stiffer and cytoadherent and these two outcomes can lead to microvascular blockage. We propose a numerical model of the three-dimensional hemodynamics in malaria infection. Our model is based on a Lagrangian and free mesh method (particle method). We employ spring network of membrane particles for representing deformation of RBC membrane. Adhesive property of IRBCs to surrounding cells is also expressed by using a spring model. Our method would be helpful for further understandings of pathology of malaria-infection.

Original language	English
Title of host publication	World Congress on Medical Physics and Biomedical Engineering
Subtitle of host publication	Image Processing, Biosignal Processing, Modelling and Simulation, Biomechanics
Publisher	Springer Verlag
Pages	393-394
Number of pages	2
Edition	4
ISBN (Print)	9783642038815
DOIs	https://doi.org/10.1007/978-3-642-03882-2_104
Publication status	Published - 2009
Event	World Congress on Medical Physics and Biomedical Engineering: Image Processing, Biosignal Processing, Modelling and Simulation, Biomechanics - Munich, Germany Duration: 2009 Sept 7 → 2009 Sept 12

Publication series

Name	IFMBE Proceedings
Number	4
Volume	25
ISSN (Print)	1680-0737

Other

Other	World Congress on Medical Physics and Biomedical Engineering: Image Processing, Biosignal Processing, Modelling and Simulation, Biomechanics
Country/Territory	Germany
City	Munich
Period	09/9/7 → 09/9/12

Keywords

Computational fluid dynamics
Hemodynamics
Malaria
Micro circulation
Particle method
Red blood cell

ASJC Scopus subject areas

Bioengineering
Biomedical Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-3-642-03882-2_104

Cite this

Yamaguchi, T., Kang, Y. H., Kondo, H., Imai, Y., & Ishikawa, T. (2009). Particle method simulation of red blood cells infected by malaria. In World Congress on Medical Physics and Biomedical Engineering: Image Processing, Biosignal Processing, Modelling and Simulation, Biomechanics (4 ed., pp. 393-394). (IFMBE Proceedings; Vol. 25, No. 4). Springer Verlag. https://doi.org/10.1007/978-3-642-03882-2_104

Particle method simulation of red blood cells infected by malaria. / Yamaguchi, Takami; Kang, Young Ho; Kondo, Hitoshi et al.

World Congress on Medical Physics and Biomedical Engineering: Image Processing, Biosignal Processing, Modelling and Simulation, Biomechanics. 4. ed. Springer Verlag, 2009. p. 393-394 (IFMBE Proceedings; Vol. 25, No. 4).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Yamaguchi, T, Kang, YH, Kondo, H, Imai, Y & Ishikawa, T 2009, Particle method simulation of red blood cells infected by malaria. in World Congress on Medical Physics and Biomedical Engineering: Image Processing, Biosignal Processing, Modelling and Simulation, Biomechanics. 4 edn, IFMBE Proceedings, no. 4, vol. 25, Springer Verlag, pp. 393-394, World Congress on Medical Physics and Biomedical Engineering: Image Processing, Biosignal Processing, Modelling and Simulation, Biomechanics, Munich, Germany, 09/9/7. https://doi.org/10.1007/978-3-642-03882-2_104

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abstract = "When a malaria parasite invades and matures inside a red blood cell (RBC), the infected RBC (IRBC) becomes stiffer and cytoadherent and these two outcomes can lead to microvascular blockage. We propose a numerical model of the three-dimensional hemodynamics in malaria infection. Our model is based on a Lagrangian and free mesh method (particle method). We employ spring network of membrane particles for representing deformation of RBC membrane. Adhesive property of IRBCs to surrounding cells is also expressed by using a spring model. Our method would be helpful for further understandings of pathology of malaria-infection.",

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AB - When a malaria parasite invades and matures inside a red blood cell (RBC), the infected RBC (IRBC) becomes stiffer and cytoadherent and these two outcomes can lead to microvascular blockage. We propose a numerical model of the three-dimensional hemodynamics in malaria infection. Our model is based on a Lagrangian and free mesh method (particle method). We employ spring network of membrane particles for representing deformation of RBC membrane. Adhesive property of IRBCs to surrounding cells is also expressed by using a spring model. Our method would be helpful for further understandings of pathology of malaria-infection.

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Particle method simulation of red blood cells infected by malaria

Abstract

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Keywords

ASJC Scopus subject areas

UN SDGs

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