TY - JOUR
T1 - Particular human leukocyte antigen alleles are associated with biochemical traits in the Japanese population
AU - Mitsunaga, Shigeki
AU - Homma, Yasuhiko
AU - Narita, Akira
AU - Kashiwase, Koichi
AU - Okudaira, Yuko
AU - Shiina, Yutaka
AU - Inoue, Ituro
AU - Inoko, Hidetoshi
N1 - Funding Information:
We thank the DNA donors and supporting medical staff for making this study possible. We also thank Keiko Asami for her support as the genome medical research coordinator. This work was supported in part by a grant-in-aid for scientific research from the Japanese Ministry of Health, Labour, and Welfare . None of the authors has declared conflicts of interest.
PY - 2011/7
Y1 - 2011/7
N2 - We analyzed genetic associations among 7 biochemical traits (fasting plasma glucose, HbA1c, total cholesterol, low-density lipoprotein [LDL] cholesterol, high-density lipoprotein cholesterol, triglyceride, and uric acid) and 6 HLA loci using 1,616 individuals who visited the Health Evaluation and Promotion Center at Tokai University Hospital. Significant differences between the individuals carrying particular HLA alleles and those not carrying the alleles in certain biochemical traits were observed by Mann-Whitney U test. In female subjects, DPB1*03:01 was significantly associated with HbA1c (p = 0.0000665), and DRB1*14:03 was associated with total cholesterol concentration (p = 0.0015). In male subjects, C*14:02 demonstrated significant associations with fasting plasma glucose with p values of 0.0041. By contrast, Fisher's exact test indicated that female DRB1*14:03 was associated with a high concentration of total cholesterol (p = 000323, odds ratio [OR] = 4.32, 95% confidence interval [95% CI] = 1.83-10.36), whereas female DPB1*02:01 had a protective effect against a high concentration of LDL cholesterol (p =0.0043, OR = 0.41, 95% CI = 0.19-0.79). These associations have a statistical power of more than 0.8 and still retain significance after Bonferroni correction.
AB - We analyzed genetic associations among 7 biochemical traits (fasting plasma glucose, HbA1c, total cholesterol, low-density lipoprotein [LDL] cholesterol, high-density lipoprotein cholesterol, triglyceride, and uric acid) and 6 HLA loci using 1,616 individuals who visited the Health Evaluation and Promotion Center at Tokai University Hospital. Significant differences between the individuals carrying particular HLA alleles and those not carrying the alleles in certain biochemical traits were observed by Mann-Whitney U test. In female subjects, DPB1*03:01 was significantly associated with HbA1c (p = 0.0000665), and DRB1*14:03 was associated with total cholesterol concentration (p = 0.0015). In male subjects, C*14:02 demonstrated significant associations with fasting plasma glucose with p values of 0.0041. By contrast, Fisher's exact test indicated that female DRB1*14:03 was associated with a high concentration of total cholesterol (p = 000323, odds ratio [OR] = 4.32, 95% confidence interval [95% CI] = 1.83-10.36), whereas female DPB1*02:01 had a protective effect against a high concentration of LDL cholesterol (p =0.0043, OR = 0.41, 95% CI = 0.19-0.79). These associations have a statistical power of more than 0.8 and still retain significance after Bonferroni correction.
KW - Association
KW - Biochemical trait
KW - HLA
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U2 - 10.1016/j.humimm.2011.03.011
DO - 10.1016/j.humimm.2011.03.011
M3 - Article
C2 - 21510991
AN - SCOPUS:79958291364
SN - 0198-8859
VL - 72
SP - 566
EP - 570
JO - Human Immunology
JF - Human Immunology
IS - 7
ER -