TY - JOUR
T1 - Paternal height has an impact on birth weight of their offspring in a Japanese population
T2 - The Japan Environment and Children's Study
AU - Takagi, K.
AU - Iwama, N.
AU - Metoki, H.
AU - Uchikura, Y.
AU - Matsubara, Y.
AU - Matsubara, K.
AU - Nishigori, H.
AU - Saito, M.
AU - Fujiwara, I.
AU - Sakurai, K.
AU - Kuriyama, S.
AU - Arima, T.
AU - Nakai, K.
AU - Yaegashi, N.
AU - Sugiyama, T.
N1 - Funding Information:
Takagi K. 1 Iwama N. 2 Metoki H. 3 Uchikura Y. 1 Matsubara Y. 1 Matsubara K. 1 Nishigori H. 2 Saito M. 2 Fujiwara I. 2 Sakurai K. 4 Kuriyama S. 4 5 6 Arima T. 7 Nakai K. 8 Yaegashi N. 2 Sugiyama T. 1 the Japan Environment and Children’s Study Group 1 Department of Obstetrics and Gynecology , Ehime University Graduate School of Medicine , Toon , Ehime , Japan 2 Department of Obstetrics and Gynecology , Tohoku University Graduate School of Medicine , Sendai , Miyagi , Japan 3 Department of Public Health and Hygiene , Tohoku Medical and Pharmaceutical University School of Medicine , Sendai , Miyagi , Japan 4 Environment and Genome Research Center , Tohoku University Graduate School of Medicine , Sendai , Miyagi , Japan 5 Department of Preventive Medicine and Epidemiology , Tohoku Medical Megabank Organization , Tohoku University , Sendai , Miyagi , Japan 6 Department of Disaster Public Health , International Research Institute of Disaster Science , Tohoku University , Sendai , Miyagi , Japan 7 Department of Informative Genetics , Tohoku University Graduate School of Medicine , Sendai , Japan 8 Department of Development and Environmental Medicine , Tohoku University Graduate School of Medicine , Sendai , Japan Address for correspondence: Takashi Sugiyama, MD, Department of Obstetrics and Gynecology, Ehime University School of Medicine, Ehime 791-0295, Japan E-mail: sugiyama@m.ehime-u.ac.jp 10 2019 11 02 2019 10 5 542 554 21 08 2018 21 11 2018 17 12 2018 © Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2019 This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence ( http://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. 2019 Cambridge University Press and the International Society for Developmental Origins of Health and Disease This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence ( http://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Funding Information:
The Japan Environment and Childrens Study was funded by the Ministry of the Environment, Japan. The findings and conclusions of this article are solely the responsibility of the authors and do not represent the official views of the above government.
Publisher Copyright:
© 2019 Cambridge University Press and the International Society for Developmental Origins of Health and Disease.
PY - 2019/10/1
Y1 - 2019/10/1
N2 - This study examines the relationship between paternal height or body mass index (BMI) and birth weight of their offspring in a Japanese general population. The sample included 33,448 pregnant Japanese women and used fixed data, including maternal, paternal and infant characteristics, from the Japan Environment and Children's Study (JECS), an ongoing nationwide birth cohort study. Relationships between paternal height or BMI and infant birth weight [i.e., small for gestational age (SGA) and large for gestational age (LGA)] were examined using a multinomial logistic regression model. Since fetal programming may be a sex-specific process, male and female infants were analyzed separately. Multivariate analysis showed that the higher the paternal height, the higher the odds of LGA and the lower the odds of SGA in both male and female infants. The effects of paternal BMI on the odds of both SGA and LGA in male infants were similar to those of paternal height; however, paternal height had a stronger impact than BMI on the odds of male LGA. In addition, paternal BMI showed no association with the odds of SGA and only a weak association with the odds of LGA in female infants. This cohort study showed that paternal height was associated with birth weight of their offspring and had stronger effects than paternal BMI, suggesting that the impact of paternal height on infant birth weight could be explained by genetic factors. The sex-dependent effect of paternal BMI on infant birth weight may be due to epigenetic effects.
AB - This study examines the relationship between paternal height or body mass index (BMI) and birth weight of their offspring in a Japanese general population. The sample included 33,448 pregnant Japanese women and used fixed data, including maternal, paternal and infant characteristics, from the Japan Environment and Children's Study (JECS), an ongoing nationwide birth cohort study. Relationships between paternal height or BMI and infant birth weight [i.e., small for gestational age (SGA) and large for gestational age (LGA)] were examined using a multinomial logistic regression model. Since fetal programming may be a sex-specific process, male and female infants were analyzed separately. Multivariate analysis showed that the higher the paternal height, the higher the odds of LGA and the lower the odds of SGA in both male and female infants. The effects of paternal BMI on the odds of both SGA and LGA in male infants were similar to those of paternal height; however, paternal height had a stronger impact than BMI on the odds of male LGA. In addition, paternal BMI showed no association with the odds of SGA and only a weak association with the odds of LGA in female infants. This cohort study showed that paternal height was associated with birth weight of their offspring and had stronger effects than paternal BMI, suggesting that the impact of paternal height on infant birth weight could be explained by genetic factors. The sex-dependent effect of paternal BMI on infant birth weight may be due to epigenetic effects.
KW - body mass index
KW - Japan Environment and Children's Study
KW - large for gestational age
KW - paternal
KW - pregnancy
KW - small for gestational age
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U2 - 10.1017/S2040174418001162
DO - 10.1017/S2040174418001162
M3 - Article
C2 - 30739616
AN - SCOPUS:85061355365
SN - 2040-1744
VL - 10
SP - 542
EP - 554
JO - Journal of Developmental Origins of Health and Disease
JF - Journal of Developmental Origins of Health and Disease
IS - 5
ER -