Pathophysiological roles of ASK1-MAP kinase signaling pathways

Hiroaki Nagai, Takuya Noguchi, Kohsuke Takeda, Hidenori Ichijo

Research output: Contribution to journalReview articlepeer-review

214 Citations (Scopus)


Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase (MAPK) kinase kinase that activates JNK and p38 kinases. ASK1 is activated by various stresses, such as reactive oxygen species (ROS), endoplasmic reticulum (ER) stress, lipopolysaccharide (LPS) and calcium influx which are thought to be responsible for the pathogenesis or exacerbations of various human diseases. Recent studies revealed the involvement of ASK1 in ROS- or ER stress-related diseases, suggesting that ASK1 may be a potential therapeutic target of various human diseases. In this review, we focus on the current findings for the relationship between pathogenesis and ASK1-MAPK pathways.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalJournal of Biochemistry and Molecular Biology
Issue number1
Publication statusPublished - 2007 Jan


  • ASK1
  • ER stress
  • Innate immunity
  • MAPK
  • Oxidative stress


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