Pazopanib-induced crystal deposition in intestinal mucosa in a patient with retroperitoneal liposarcoma

Shigemitsu Horie; Hayato Nishida; Toshihiko Sakurai; Osamu Ichiyanagi; Tomoyuki Kato; Makoto Yagi; Takanobu Kabasawa; Teigo Asai; Norihiko Tsuchiya

doi:10.1111/iju.13567

Pazopanib-induced crystal deposition in intestinal mucosa in a patient with retroperitoneal liposarcoma

Shigemitsu Horie, Hayato Nishida, Toshihiko Sakurai, Osamu Ichiyanagi, Tomoyuki Kato, Makoto Yagi, Takanobu Kabasawa, Teigo Asai, Norihiko Tsuchiya

PHA - Molecular Pharmaceutical Science

Yamagata University

Research output: Contribution to journal › Article › peer-review

Abstract

Pazopanib was administered to a 44-year-old man with local recurrence of retroperitoneal liposarcoma. Computed tomography showed an intestinal edema, which gradually progressed 15 months after pazopanib administration although he had no clinical symptoms. Upper gastrointestinal endoscopy implicated marked edematous hypertrophy of the Kerkling's fold. Pathological findings showed crystal deposition and fat accumulation, without a malignant component. All these abnormal findings resolved after pazopanib discontinuation.

Original language	English
Pages (from-to)	627-629
Number of pages	3
Journal	International Journal of Urology
Volume	25
Issue number	6
DOIs	https://doi.org/10.1111/iju.13567
Publication status	Published - 2018 Jun

Keywords

intestinal edema
liposarcoma
mucosal crystallization
pazopanib
tyrosine kinase inhibitor

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title = "Pazopanib-induced crystal deposition in intestinal mucosa in a patient with retroperitoneal liposarcoma",

abstract = "Pazopanib was administered to a 44-year-old man with local recurrence of retroperitoneal liposarcoma. Computed tomography showed an intestinal edema, which gradually progressed 15 months after pazopanib administration although he had no clinical symptoms. Upper gastrointestinal endoscopy implicated marked edematous hypertrophy of the Kerkling's fold. Pathological findings showed crystal deposition and fat accumulation, without a malignant component. All these abnormal findings resolved after pazopanib discontinuation.",

keywords = "intestinal edema, liposarcoma, mucosal crystallization, pazopanib, tyrosine kinase inhibitor",

author = "Shigemitsu Horie and Hayato Nishida and Toshihiko Sakurai and Osamu Ichiyanagi and Tomoyuki Kato and Makoto Yagi and Takanobu Kabasawa and Teigo Asai and Norihiko Tsuchiya",

note = "Publisher Copyright: {\textcopyright} 2018 The Japanese Urological Association",

year = "2018",

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doi = "10.1111/iju.13567",

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AU - Horie, Shigemitsu

AU - Nishida, Hayato

AU - Sakurai, Toshihiko

AU - Ichiyanagi, Osamu

AU - Kato, Tomoyuki

AU - Yagi, Makoto

AU - Kabasawa, Takanobu

AU - Asai, Teigo

AU - Tsuchiya, Norihiko

PY - 2018/6

Y1 - 2018/6

N2 - Pazopanib was administered to a 44-year-old man with local recurrence of retroperitoneal liposarcoma. Computed tomography showed an intestinal edema, which gradually progressed 15 months after pazopanib administration although he had no clinical symptoms. Upper gastrointestinal endoscopy implicated marked edematous hypertrophy of the Kerkling's fold. Pathological findings showed crystal deposition and fat accumulation, without a malignant component. All these abnormal findings resolved after pazopanib discontinuation.

AB - Pazopanib was administered to a 44-year-old man with local recurrence of retroperitoneal liposarcoma. Computed tomography showed an intestinal edema, which gradually progressed 15 months after pazopanib administration although he had no clinical symptoms. Upper gastrointestinal endoscopy implicated marked edematous hypertrophy of the Kerkling's fold. Pathological findings showed crystal deposition and fat accumulation, without a malignant component. All these abnormal findings resolved after pazopanib discontinuation.

KW - intestinal edema

KW - liposarcoma

KW - mucosal crystallization

KW - pazopanib

KW - tyrosine kinase inhibitor

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Pazopanib-induced crystal deposition in intestinal mucosa in a patient with retroperitoneal liposarcoma

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