Pd-catalyzed β-selective direct C-H bond arylation of thiophenes with aryltrimethylsilanes

Kenji Funaki; Tetsuo Sato; Shuichi Oi

doi:10.1021/ol3029109

Pd-catalyzed β-selective direct C-H bond arylation of thiophenes with aryltrimethylsilanes

Kenji Funaki, Tetsuo Sato, Shuichi Oi

Environment Conservation Center

Tohoku University

Research output: Contribution to journal › Article › peer-review

85 Citations (Scopus)

Abstract

Direct arylation of thiophenes and benzothiophenes with aryltrimethylsilanes was effectively catalyzed by PdCl₂(MeCN) ₂ in the presence of CuCl₂ as an oxidant. The reaction preferentially occurred at the β-position of both thiophenes and benzothiophenes.

Original language	English
Pages (from-to)	6186-6189
Number of pages	4
Journal	Organic Letters
Volume	14
Issue number	24
DOIs	https://doi.org/10.1021/ol3029109
Publication status	Published - 2012 Dec 21

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title = "Pd-catalyzed β-selective direct C-H bond arylation of thiophenes with aryltrimethylsilanes",

abstract = "Direct arylation of thiophenes and benzothiophenes with aryltrimethylsilanes was effectively catalyzed by PdCl2(MeCN) 2 in the presence of CuCl2 as an oxidant. The reaction preferentially occurred at the β-position of both thiophenes and benzothiophenes.",

author = "Kenji Funaki and Tetsuo Sato and Shuichi Oi",

year = "2012",

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doi = "10.1021/ol3029109",

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journal = "Organic Letters",

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T1 - Pd-catalyzed β-selective direct C-H bond arylation of thiophenes with aryltrimethylsilanes

AU - Funaki, Kenji

AU - Sato, Tetsuo

AU - Oi, Shuichi

PY - 2012/12/21

Y1 - 2012/12/21

N2 - Direct arylation of thiophenes and benzothiophenes with aryltrimethylsilanes was effectively catalyzed by PdCl2(MeCN) 2 in the presence of CuCl2 as an oxidant. The reaction preferentially occurred at the β-position of both thiophenes and benzothiophenes.

AB - Direct arylation of thiophenes and benzothiophenes with aryltrimethylsilanes was effectively catalyzed by PdCl2(MeCN) 2 in the presence of CuCl2 as an oxidant. The reaction preferentially occurred at the β-position of both thiophenes and benzothiophenes.

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U2 - 10.1021/ol3029109

DO - 10.1021/ol3029109

M3 - Article

C2 - 23214502

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JO - Organic Letters

JF - Organic Letters

IS - 24

ER -

Pd-catalyzed β-selective direct C-H bond arylation of thiophenes with aryltrimethylsilanes

Abstract

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