@article{c2bedb8d90734bd1badf44764d9f2c4c,
title = "Pd-catalyzed Regio- A nd Stereoselective Hydrostannylation of an Alkyl Ethynyl Ether/One-Pot Stille Coupling Enables the Synthesis of 14-Membered Macrolactone of Luminamicin",
abstract = "Regio- A nd stereoselective hydrostannylation of alkyl ethynyl ethers generates alkenyl ethers, which are useful building blocks in organic synthesis. This efficient synthetic method, however, is limited. Here, we report not only an efficient method for a highly regio- A nd stereoselective Pd-catalyzed hydrostannylation of alkyl ethynyl ethers but also a scalable synthesis and construction of the core framework of luminamicin possessing all functional groups and stereocenters.",
author = "Akihiro Sugawara and Hirokazu Takada and Tomoyasu Hirose and Aoi Kimishima and Takeshi Yamada and Masaki Toda and Toru Kojima and Takanori Matsumaru and Toshiaki Sunazuka",
note = "Funding Information: We are grateful to Distinguished Emeritus Professor Satoshi O̅mura (Kitasato University) for his helpful support and valuable suggestions. This work was supported by Japan Society for the Promotion of Science (JSPS) KAKENHI grants (Nos. 16K08175, 26860015, 24790022, 22890175 (A.S.), and 18K06586 (T.H.)), a Meiji Seika Pharma Award in Synthetic Organic Chemistry Japan (A.S.); a Kitasato University Research Grant for Young Researchers (A.S.), JSPS Research Fellowships for Young Scientists (T.M. and A.K.), and a Uehara Memorial foundation grant (T.H.). This research was also partially supported by Platform Project for Supporting Drug Discovery and Life Science Research (Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS)) from AMED under Grant No. JP20am0101096 and AMED under Grant No. 20ae0101047. We also thank Dr. K. Nagai and Ms. N. Sato (School of Pharmacy, Kitasato University) for their analyses of mass and NMR spectra. Publisher Copyright: {\textcopyright} 2021 American Chemical Society. All rights reserved.",
year = "2021",
month = mar,
day = "5",
doi = "10.1021/acs.orglett.1c00183",
language = "English",
volume = "23",
pages = "1758--1763",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "5",
}