@article{a1d19bb767c84e7597d3114e1209d97f,
title = "Peptide drug release behavior from biodegradable temperature-responsive injectable hydrogels exhibiting irreversible gelation",
abstract = "We investigated the release behavior of glucagon-like peptide-1 (GLP-1) from a biodegradable injectable polymer (IP) hydrogel. This hydrogel shows temperature-responsive irreversible gelation due to the covalent bond formation through a thiol-ene reaction. In vitro sustained release of GLP-1 from an irreversible IP formulation (F(P1/D+PA40)) was observed compared with a reversible (physical gelation) IP formulation (F(P1)). Moreover, pharmaceutically active levels of GLP-1 were maintained in blood after subcutaneous injection of the irreversible IP formulation into rats. This system should be useful for the minimally invasive sustained drug release of peptide drugs and other water-soluble bioactive reagents.",
keywords = "Hydrogel, Injectable polymers, Peptide drug delivery, Sol-to-gel transition, Sustained release",
author = "Kazuyuki Takata and Hiroki Takai and Yuta Yoshizaki and Takuya Nagata and Keisuke Kawahara and Yasuyuki Yoshida and Akinori Kuzuya and Yuichi Ohya",
note = "Funding Information: This work was financially supported in part by Private University Research Branding Project: Matching Fund Subsidy from Ministry of Education, Culture, Sports, Science and Technology (MEXT) Japan (2016–2020), a Grant-in-Aid for Scientific Research (16H01854) from the Japan Society for the Promotion of Science (JSPS), and by the Kansai University Outlay Support for Establishing Research Centers, 2016. The authors thank SC Organic Chemical Co. Ltd. for providing DPMP. Funding Information: Acknowledgments: This work was financially supported in part by Private University Research Branding Project: Matching Fund Subsidy from Ministry of Education, Culture, Sports, Science and Technology (MEXT) Japan (2016–2020), a Grant-in-Aid for Scientific Research (16H01854) from the Japan Society for the Promotion of Science (JSPS), and by the Kansai University Outlay Support for Establishing Research Centers, 2016. The authors thank SC Organic Chemical Co. Ltd. for providing DPMP. Publisher Copyright: {\textcopyright} 2017 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2017",
month = dec,
doi = "10.3390/gels3040038",
language = "English",
volume = "3",
journal = "Gels",
issn = "2310-2861",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "4",
}