TY - JOUR
T1 - Peptidoglycan recognition proteins in Drosophila immunity
AU - Kurata, Shoichiro
N1 - Funding Information:
This work was supported by Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan ; the Japan Society for the Promotion of Science ; Japan Science and Technology Agency ; the Program for the Promotion of Basic Research Activities for Innovative Biosciences (PROBRAIN) ; the Strategic International Cooperative program from the Japan Science and Technology Agency ; the National Institutes of Health ( AI07495 ); the Takeda Science Foundation ; the Mitsubishi Foundation ; Astellas Foundation for Research on Metabolic Disorders ; the Uehara Memorial Foundation ; the Naito Foundation ; Mochida Memorial Foundation ; Terumo Life Science Foundation ; Kowa Life Science Foundation ; and a Global COE Research Grant (Tohoku University Ecosystem Adaptability) .
PY - 2014/1
Y1 - 2014/1
N2 - Innate immunity is the front line of self-defense against infectious non-self in vertebrates and invertebrates. The innate immune system is mediated by germ-line encoding pattern recognition molecules (pathogen sensors) that recognize conserved molecular patterns present in the pathogens but absent in the host. Peptidoglycans (PGN) are essential cell wall components of almost all bacteria, except mycoplasma lacking a cell wall, which provides the host immune system an advantage for detecting invading bacteria. Several families of pattern recognition molecules that detect PGN and PGN-derived compounds have been indentified, and the role of PGRP family members in host defense is relatively well-characterized in Drosophila. This review focuses on the role of PGRP family members in the recognition of invading bacteria and the activation and modulation of immune responses in Drosophila.
AB - Innate immunity is the front line of self-defense against infectious non-self in vertebrates and invertebrates. The innate immune system is mediated by germ-line encoding pattern recognition molecules (pathogen sensors) that recognize conserved molecular patterns present in the pathogens but absent in the host. Peptidoglycans (PGN) are essential cell wall components of almost all bacteria, except mycoplasma lacking a cell wall, which provides the host immune system an advantage for detecting invading bacteria. Several families of pattern recognition molecules that detect PGN and PGN-derived compounds have been indentified, and the role of PGRP family members in host defense is relatively well-characterized in Drosophila. This review focuses on the role of PGRP family members in the recognition of invading bacteria and the activation and modulation of immune responses in Drosophila.
KW - Antimicrobial defense
KW - Drosophila
KW - Innate immunity
KW - Pattern recognition receptor
KW - Peptidoglycan recognition protein
KW - Prophenoloxidase cascade
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U2 - 10.1016/j.dci.2013.06.006
DO - 10.1016/j.dci.2013.06.006
M3 - Article
C2 - 23796791
AN - SCOPUS:84886099320
SN - 0145-305X
VL - 42
SP - 36
EP - 41
JO - Developmental and Comparative Immunology
JF - Developmental and Comparative Immunology
IS - 1
ER -