Percutaneous transluminal pulmonary angioplasty markedly improves pulmonary hemodynamics and long-term prognosis in patients with chronic thromboembolic pulmonary hypertension

Koichiro Sugimura; Yoshihiro Fukumoto; Kimio Satoh; Kotaro Nochioka; Yutaka Miura; Tatsuo Aoki; Shunsuke Tatebe; Saori Miyamichi-Yamamoto; Hiroaki Shimokawa

doi:10.1253/circj.CJ-11-1217

Percutaneous transluminal pulmonary angioplasty markedly improves pulmonary hemodynamics and long-term prognosis in patients with chronic thromboembolic pulmonary hypertension

Koichiro Sugimura, Yoshihiro Fukumoto, Kimio Satoh, Kotaro Nochioka, Yutaka Miura, Tatsuo Aoki, Shunsuke Tatebe, Saori Miyamichi-Yamamoto, Hiroaki Shimokawa

Tohoku University

Research output: Contribution to journal › Article › peer-review

270 Citations (Scopus)

Abstract

Background: Distal-type chronic thromboembolic pulmonary hypertension (CTEPH) is a fatal disease for which a new therapeutic strategy needs to be developed. We examined the effects of percutaneous transluminal pulmonary angioplasty (PTPA). Methods and Results: We prospectively enrolled 12 patients with distal-type CTEPH. After stabilizing their condition with pulmonary vasodilators, we then performed PTPA, which markedly improved pulmonary hemodynamics and pulmonary artery structure, as confirmed by angiography and optical coherence tomography, and also significantly improved their long-term prognosis compared with 39 historical controls. Conclusions: PTPA is a promising therapeutic option for distal-type CTEPH.

Original language	English
Pages (from-to)	485-488
Number of pages	4
Journal	Circulation Journal
Volume	76
Issue number	2
DOIs	https://doi.org/10.1253/circj.CJ-11-1217
Publication status	Published - 2012

Keywords

Chronic thromboembolic pulmonary hypertension
Optical coherence tomography
Percutaneous transluminal pulmonary angioplasty

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10.1253/circj.CJ-11-1217

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Sugimura, K., Fukumoto, Y., Satoh, K., Nochioka, K., Miura, Y., Aoki, T., Tatebe, S., Miyamichi-Yamamoto, S., & Shimokawa, H. (2012). Percutaneous transluminal pulmonary angioplasty markedly improves pulmonary hemodynamics and long-term prognosis in patients with chronic thromboembolic pulmonary hypertension. Circulation Journal, 76(2), 485-488. https://doi.org/10.1253/circj.CJ-11-1217

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title = "Percutaneous transluminal pulmonary angioplasty markedly improves pulmonary hemodynamics and long-term prognosis in patients with chronic thromboembolic pulmonary hypertension",

abstract = "Background: Distal-type chronic thromboembolic pulmonary hypertension (CTEPH) is a fatal disease for which a new therapeutic strategy needs to be developed. We examined the effects of percutaneous transluminal pulmonary angioplasty (PTPA). Methods and Results: We prospectively enrolled 12 patients with distal-type CTEPH. After stabilizing their condition with pulmonary vasodilators, we then performed PTPA, which markedly improved pulmonary hemodynamics and pulmonary artery structure, as confirmed by angiography and optical coherence tomography, and also significantly improved their long-term prognosis compared with 39 historical controls. Conclusions: PTPA is a promising therapeutic option for distal-type CTEPH.",

keywords = "Chronic thromboembolic pulmonary hypertension, Optical coherence tomography, Percutaneous transluminal pulmonary angioplasty",

author = "Koichiro Sugimura and Yoshihiro Fukumoto and Kimio Satoh and Kotaro Nochioka and Yutaka Miura and Tatsuo Aoki and Shunsuke Tatebe and Saori Miyamichi-Yamamoto and Hiroaki Shimokawa",

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Sugimura, K, Fukumoto, Y, Satoh, K, Nochioka, K, Miura, Y, Aoki, T, Tatebe, S , Miyamichi-Yamamoto, S & Shimokawa, H 2012, 'Percutaneous transluminal pulmonary angioplasty markedly improves pulmonary hemodynamics and long-term prognosis in patients with chronic thromboembolic pulmonary hypertension', Circulation Journal, vol. 76, no. 2, pp. 485-488. https://doi.org/10.1253/circj.CJ-11-1217

TY - JOUR

T1 - Percutaneous transluminal pulmonary angioplasty markedly improves pulmonary hemodynamics and long-term prognosis in patients with chronic thromboembolic pulmonary hypertension

AU - Sugimura, Koichiro

AU - Fukumoto, Yoshihiro

AU - Satoh, Kimio

AU - Nochioka, Kotaro

AU - Miura, Yutaka

AU - Aoki, Tatsuo

AU - Tatebe, Shunsuke

AU - Miyamichi-Yamamoto, Saori

AU - Shimokawa, Hiroaki

PY - 2012

Y1 - 2012

N2 - Background: Distal-type chronic thromboembolic pulmonary hypertension (CTEPH) is a fatal disease for which a new therapeutic strategy needs to be developed. We examined the effects of percutaneous transluminal pulmonary angioplasty (PTPA). Methods and Results: We prospectively enrolled 12 patients with distal-type CTEPH. After stabilizing their condition with pulmonary vasodilators, we then performed PTPA, which markedly improved pulmonary hemodynamics and pulmonary artery structure, as confirmed by angiography and optical coherence tomography, and also significantly improved their long-term prognosis compared with 39 historical controls. Conclusions: PTPA is a promising therapeutic option for distal-type CTEPH.

AB - Background: Distal-type chronic thromboembolic pulmonary hypertension (CTEPH) is a fatal disease for which a new therapeutic strategy needs to be developed. We examined the effects of percutaneous transluminal pulmonary angioplasty (PTPA). Methods and Results: We prospectively enrolled 12 patients with distal-type CTEPH. After stabilizing their condition with pulmonary vasodilators, we then performed PTPA, which markedly improved pulmonary hemodynamics and pulmonary artery structure, as confirmed by angiography and optical coherence tomography, and also significantly improved their long-term prognosis compared with 39 historical controls. Conclusions: PTPA is a promising therapeutic option for distal-type CTEPH.

KW - Chronic thromboembolic pulmonary hypertension

KW - Optical coherence tomography

KW - Percutaneous transluminal pulmonary angioplasty

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AN - SCOPUS:84856239291

SN - 1346-9843

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JO - Circulation Journal

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Percutaneous transluminal pulmonary angioplasty markedly improves pulmonary hemodynamics and long-term prognosis in patients with chronic thromboembolic pulmonary hypertension

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