TY - JOUR
T1 - Periodontal status and lung function decline in the community
T2 - the Hisayama study
AU - Takeuchi, Kenji
AU - Matsumoto, Koichiro
AU - Furuta, Michiko
AU - Fukuyama, Satoru
AU - Takeshita, Toru
AU - Ogata, Hiroaki
AU - Suma, Shino
AU - Shibata, Yukie
AU - Shimazaki, Yoshihiro
AU - Hata, Jun
AU - Ninomiya, Toshiharu
AU - Nakanishi, Yoichi
AU - Inoue, Hiromasa
AU - Yamashita, Yoshihisa
N1 - Funding Information:
The authors are grateful to the staff of the Division of Health and Welfare of the Hisayama Town Office for their cooperation in this study. This study was supported by Japan Society for the Promotion of Science (JSPS) KAKENHI Grant Numbers JP16H05557, JP16H05850, JP17K17375 and Japan Agency for Medical Research and Development (AMED). The funders had no role in the study design, study management, data collection, data analysis, data interpretation, or preparetion of the manuscript.
Publisher Copyright:
© 2018, The Author(s).
PY - 2018/12/1
Y1 - 2018/12/1
N2 - This study aimed to determine whether periodontal status is related to a decline in lung function in a general Japanese population. We followed a total of 1,650 community-dwelling individuals (≥40 years) without chronic obstructive pulmonary disease, with at least one teeth, for 3 years. Periodontal status was assessed at baseline by clinical attachment loss (CAL) and probing pocket depth (PPD) at two sites for each tooth, and the mean values were calculated for each subject. Lung function was measured at baseline and follow-up using spirometry, and longitudinal decline in forced expiratory volume in one second (FEV1) was calculated. Multivariate Poisson regression with robust error variance was used to estimate risk ratio (RR). After adjusting for potential confounders including smoking status, there was a tendency for the adjusted RR of developing rapid lung function decline (≥160 mL/3years, the highest quartile of the distribution of FEV1 declines) to increase as mean CAL levels increased (P trend = 0.039). Likewise, a positive association was observed between mean PPD levels and RR of developing rapid lung function decline (P trend = 0.047). Our findings suggest deterioration of periodontal status could be a risk factor for rapid lung function decline in the general Japanese population.
AB - This study aimed to determine whether periodontal status is related to a decline in lung function in a general Japanese population. We followed a total of 1,650 community-dwelling individuals (≥40 years) without chronic obstructive pulmonary disease, with at least one teeth, for 3 years. Periodontal status was assessed at baseline by clinical attachment loss (CAL) and probing pocket depth (PPD) at two sites for each tooth, and the mean values were calculated for each subject. Lung function was measured at baseline and follow-up using spirometry, and longitudinal decline in forced expiratory volume in one second (FEV1) was calculated. Multivariate Poisson regression with robust error variance was used to estimate risk ratio (RR). After adjusting for potential confounders including smoking status, there was a tendency for the adjusted RR of developing rapid lung function decline (≥160 mL/3years, the highest quartile of the distribution of FEV1 declines) to increase as mean CAL levels increased (P trend = 0.039). Likewise, a positive association was observed between mean PPD levels and RR of developing rapid lung function decline (P trend = 0.047). Our findings suggest deterioration of periodontal status could be a risk factor for rapid lung function decline in the general Japanese population.
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U2 - 10.1038/s41598-018-31610-3
DO - 10.1038/s41598-018-31610-3
M3 - Article
C2 - 30190577
AN - SCOPUS:85052922733
SN - 2045-2322
VL - 8
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 13354
ER -