Periostin in the Cancer Stroma of Mycosis Fungoides Palmaris et Plantaris: A Case Report and Immunohistochemical Study

Kayo Tanita; Taku Fujimura; Aya Kakizaki; Sadanori Furudate; Masato Mizuashi; Akiko Watabe; Setsuya Aiba

doi:10.1159/000444162

Periostin in the Cancer Stroma of Mycosis Fungoides Palmaris et Plantaris: A Case Report and Immunohistochemical Study

Kayo Tanita, Taku Fujimura, Aya Kakizaki, Sadanori Furudate, Masato Mizuashi, Akiko Watabe, Setsuya Aiba

MED - Medical Sciences

Tohoku University

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Mycosis fungoides palmaris et plantaris (MFPP) is a rare variant of mycosis fungoides limited to the palms and soles. Although little is known about the pathogenesis of MFPP, this variant of mycosis fungoides presents a relatively good prognosis. In this report, we describe an 85-year-old Japanese man with MFPP. Immunohistochemical staining revealed the dense deposition of periostin in the cancer stroma, as well as infiltration of CD163⁺CD206^- tumor-associated macrophages (TAMs), which suggested the phenotypes of TAMs were not polarized to the M2 phenotype in the lesional skin of MFPP. Our present case might suggest one of the possible reasons for the good prognosis of MFPP.

Original language	English
Pages (from-to)	31-35
Number of pages	5
Journal	Case Reports in Dermatology
Volume	8
Issue number	1
DOIs	https://doi.org/10.1159/000444162
Publication status	Published - 2016

Keywords

M2 polarization
Mycosis fungoides palmaris et plantaris
Periostin
Prognosis
Tumor-associated macrophages

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Periostin in the Cancer Stroma of Mycosis Fungoides Palmaris et Plantaris: A Case Report and Immunohistochemical Study",

abstract = "Mycosis fungoides palmaris et plantaris (MFPP) is a rare variant of mycosis fungoides limited to the palms and soles. Although little is known about the pathogenesis of MFPP, this variant of mycosis fungoides presents a relatively good prognosis. In this report, we describe an 85-year-old Japanese man with MFPP. Immunohistochemical staining revealed the dense deposition of periostin in the cancer stroma, as well as infiltration of CD163+CD206- tumor-associated macrophages (TAMs), which suggested the phenotypes of TAMs were not polarized to the M2 phenotype in the lesional skin of MFPP. Our present case might suggest one of the possible reasons for the good prognosis of MFPP.",

keywords = "M2 polarization, Mycosis fungoides palmaris et plantaris, Periostin, Prognosis, Tumor-associated macrophages",

author = "Kayo Tanita and Taku Fujimura and Aya Kakizaki and Sadanori Furudate and Masato Mizuashi and Akiko Watabe and Setsuya Aiba",

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doi = "10.1159/000444162",

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volume = "8",

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T1 - Periostin in the Cancer Stroma of Mycosis Fungoides Palmaris et Plantaris

T2 - A Case Report and Immunohistochemical Study

AU - Tanita, Kayo

AU - Fujimura, Taku

AU - Kakizaki, Aya

AU - Furudate, Sadanori

AU - Mizuashi, Masato

AU - Watabe, Akiko

AU - Aiba, Setsuya

PY - 2016

Y1 - 2016

N2 - Mycosis fungoides palmaris et plantaris (MFPP) is a rare variant of mycosis fungoides limited to the palms and soles. Although little is known about the pathogenesis of MFPP, this variant of mycosis fungoides presents a relatively good prognosis. In this report, we describe an 85-year-old Japanese man with MFPP. Immunohistochemical staining revealed the dense deposition of periostin in the cancer stroma, as well as infiltration of CD163+CD206- tumor-associated macrophages (TAMs), which suggested the phenotypes of TAMs were not polarized to the M2 phenotype in the lesional skin of MFPP. Our present case might suggest one of the possible reasons for the good prognosis of MFPP.

AB - Mycosis fungoides palmaris et plantaris (MFPP) is a rare variant of mycosis fungoides limited to the palms and soles. Although little is known about the pathogenesis of MFPP, this variant of mycosis fungoides presents a relatively good prognosis. In this report, we describe an 85-year-old Japanese man with MFPP. Immunohistochemical staining revealed the dense deposition of periostin in the cancer stroma, as well as infiltration of CD163+CD206- tumor-associated macrophages (TAMs), which suggested the phenotypes of TAMs were not polarized to the M2 phenotype in the lesional skin of MFPP. Our present case might suggest one of the possible reasons for the good prognosis of MFPP.

KW - M2 polarization

KW - Mycosis fungoides palmaris et plantaris

KW - Periostin

KW - Prognosis

KW - Tumor-associated macrophages

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Periostin in the Cancer Stroma of Mycosis Fungoides Palmaris et Plantaris: A Case Report and Immunohistochemical Study

Abstract

Keywords

UN SDGs

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