TY - JOUR
T1 - Peripheral blood monocyte count at onset may affect the prognosis in multiple sclerosis
AU - Akaishi, Tetsuya
AU - Takahashi, Toshiyuki
AU - Nakashima, Ichiro
N1 - Funding Information:
Ichiro Nakashima – Received Funding for a trip and presentations from Biogen Japan, Mitsubishi Tanabe Pharma, Novartis Pharma, and Takeda Pharmaceutical Company, served as an editorial board member of Multiple Sclerosis International, and received grant support from LSI Medience Corporation.
Publisher Copyright:
© 2018 Elsevier B.V.
PY - 2018/6/15
Y1 - 2018/6/15
N2 - Multiple sclerosis (MS) is a demyelinating neurological disease with unknown causes. In this study, we comprehensively studied blood cell counts in the early phase of MS and compared their values with eventual prognostic variables. We found that the blood monocyte count in the early phase of MS was robustly associated with the clinical severity of MS (rho = 0.64; p = 0.0002) but that the counts of the other blood cells were not associated with severity. This correlation between monocyte count and severity was not observed in neuromyelitis optica. In conclusion, blood monocytes could be a candidate for the prognostic prediction of MS.
AB - Multiple sclerosis (MS) is a demyelinating neurological disease with unknown causes. In this study, we comprehensively studied blood cell counts in the early phase of MS and compared their values with eventual prognostic variables. We found that the blood monocyte count in the early phase of MS was robustly associated with the clinical severity of MS (rho = 0.64; p = 0.0002) but that the counts of the other blood cells were not associated with severity. This correlation between monocyte count and severity was not observed in neuromyelitis optica. In conclusion, blood monocytes could be a candidate for the prognostic prediction of MS.
KW - Aggravating factor
KW - Monocyte
KW - Multiple sclerosis
KW - Prognosis
KW - Severity
UR - http://www.scopus.com/inward/record.url?scp=85044728602&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85044728602&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2018.03.016
DO - 10.1016/j.jneuroim.2018.03.016
M3 - Article
C2 - 29685288
AN - SCOPUS:85044728602
SN - 0165-5728
VL - 319
SP - 37
EP - 40
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
ER -