Permselectivity of voltage-gated alamethicin ion channel studied by microamperometry

Tomokazu Matsue, Hitoshi Shiku, Hiroshi Yamada, Isamu Uchida

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28 Citations (Scopus)


The permeability of Ru(NH3)63+, Fe(CN)63-, and I- through voltage-gated alamethicin ion channels in a planar lipid membrane was investigated by amperometric measurements using a microelectrode located near the membrane. The redox current at the microelectrode initiated by application of a potential pulse to the BLM was quantitatively analyzed to obtain permselectivity of the channel. The permeability of Fe(CN)63- was ca. 10 times smaller than that of Ru(NH3)63+ due to electrostatic repulsion, indicating that the channel gives a high barrier to the permeation of multicharged negative ions.

Original languageEnglish
Pages (from-to)11001-11003
Number of pages3
JournalJournal of Physical Chemistry
Issue number43
Publication statusPublished - 1994


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