TY - JOUR
T1 - Peroxydisulfate-Mediated Transition-Metal-Free Oxidative C(sp3)−H Bond Lactonization
AU - Nozawa-Kumada, Kanako
AU - Kurosu, Satoshi
AU - Shigeno, Masanori
AU - Kondo, Yoshinori
N1 - Funding Information:
This work was financially supported by the Japan Society for the Promotion of Science (JSPS) KAKENHI Grant no. 17K15418. This work was also supported by Grand for Basic Science Research Projects from The Sumitomo Foundation, the Platform Project for Supporting Drug Discovery and Life Science Research funded by Japan Agency for Medical Research and Development (AMED), Tohoku University Center for Gender Equality Promotion (TUMUG), and Morinomiyako Project for Empowering Women in Research.
Publisher Copyright:
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2019/7
Y1 - 2019/7
N2 - An inexpensive, powerful, and eco-friendly method for transition-metal-free oxidative C(sp3)−H bond lactonization was developed using sodium peroxydisulfate as the sole oxidant. The cyclization of 2-alkylbenzoic acids containing a primary, secondary or tertiary carbon at the benzylic position proceeded smoothly, affording a variety of lactone derivatives. Furthermore, various functional groups such as halogen, cyano, nitro and hydroxy groups were tolerated under the reaction conditions.
AB - An inexpensive, powerful, and eco-friendly method for transition-metal-free oxidative C(sp3)−H bond lactonization was developed using sodium peroxydisulfate as the sole oxidant. The cyclization of 2-alkylbenzoic acids containing a primary, secondary or tertiary carbon at the benzylic position proceeded smoothly, affording a variety of lactone derivatives. Furthermore, various functional groups such as halogen, cyano, nitro and hydroxy groups were tolerated under the reaction conditions.
KW - C−H functionalization
KW - lactone
KW - peroxydisulfate
KW - radical cyclization
KW - transition-metal free synthesis
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U2 - 10.1002/ajoc.201900167
DO - 10.1002/ajoc.201900167
M3 - Article
AN - SCOPUS:85065476001
SN - 2193-5807
VL - 8
SP - 1080
EP - 1083
JO - Asian Journal of Organic Chemistry
JF - Asian Journal of Organic Chemistry
IS - 7
ER -