Peroxydisulfate-Mediated Transition-Metal-Free Oxidative C(sp3)−H Bond Lactonization

Kanako Nozawa-Kumada, Satoshi Kurosu, Masanori Shigeno, Yoshinori Kondo

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


An inexpensive, powerful, and eco-friendly method for transition-metal-free oxidative C(sp3)−H bond lactonization was developed using sodium peroxydisulfate as the sole oxidant. The cyclization of 2-alkylbenzoic acids containing a primary, secondary or tertiary carbon at the benzylic position proceeded smoothly, affording a variety of lactone derivatives. Furthermore, various functional groups such as halogen, cyano, nitro and hydroxy groups were tolerated under the reaction conditions.

Original languageEnglish
Pages (from-to)1080-1083
Number of pages4
JournalAsian Journal of Organic Chemistry
Issue number7
Publication statusPublished - 2019 Jul


  • C−H functionalization
  • lactone
  • peroxydisulfate
  • radical cyclization
  • transition-metal free synthesis


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