Phase-contrast imaging with synchrotron x-rays for detecting cancer lesions

Tohoru Takeda, Atsushi Momose, Yuji Itai, Wu Jin, Keiichi Hirano

Research output: Contribution to journalArticlepeer-review

75 Citations (Scopus)


Rationale and Objectives.: We obtained image contrast in pathologic specimens without the use of contrast material by using phase-contrast imaging with synchrotron X-rays. Methods.: An experiment was performed at the three-pole superconducting vertical wiggler beam line BL-14B at the Photon Factory in Tsukuba, Japan. The X-ray phase-contrast imaging system consisted of a double crystal monochromator, an asymmetrically cut crystal monochromator, a triple Laue-case X-ray interferometer, and film. The pathologic specimen was a sample from human liver that had metastatic carcinoma. Results.: The X-ray phase-contrast images of the pathologic specimen clearly depicted the cancerous lesion without the use of contrast enhancement, and the image showed good correlation with the photograph of the specimen. The X-ray absorption image did not differentiate between the normal liver tissue and the tumor. Conclusion.: The results of this preliminary experiment reveal that for materials such as biologic specimens with a low atomic number, X-ray phase-contrast imaging better differentiates tissues than does the absorption contrast imaging commonly used in radiology.

Original languageEnglish
Pages (from-to)799-803
Number of pages5
JournalAcademic radiology
Issue number9
Publication statusPublished - 1995 Sept
Externally publishedYes


  • Phase-contrast imaging
  • X-rays
  • cancer
  • diagnostic radiology
  • interferometer
  • synchrotron radiation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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