Phenanthridine synthesis through iron-catalyzed intramolecular N-arylation of O-Acetyl oxime

Indubhusan Deb; Naohiko Yoshikai

doi:10.1021/ol4020392

Phenanthridine synthesis through iron-catalyzed intramolecular N-arylation of O-Acetyl oxime

Indubhusan Deb, Naohiko Yoshikai

PHA - Molecular Pharmaceutical Science

Nanyang Technological University

Research output: Contribution to journal › Article › peer-review

101 Citations (Scopus)

Abstract

O-Acetyl oximes derived from 2′-arylacetophenones undergo N-O bond cleavage/intramolecular N-arylation in the presence of a catalytic amount of iron(III) acetylacetonate in acetic acid. In combination with the conventional cross-coupling or directed C-H arylation, the reaction offers a convenient route to substituted phenanthridines.

Original language	English
Pages (from-to)	4254-4257
Number of pages	4
Journal	Organic Letters
Volume	15
Issue number	16
DOIs	https://doi.org/10.1021/ol4020392
Publication status	Published - 2013 Aug 16

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10.1021/ol4020392

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title = "Phenanthridine synthesis through iron-catalyzed intramolecular N-arylation of O-Acetyl oxime",

abstract = "O-Acetyl oximes derived from 2′-arylacetophenones undergo N-O bond cleavage/intramolecular N-arylation in the presence of a catalytic amount of iron(III) acetylacetonate in acetic acid. In combination with the conventional cross-coupling or directed C-H arylation, the reaction offers a convenient route to substituted phenanthridines.",

author = "Indubhusan Deb and Naohiko Yoshikai",

year = "2013",

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doi = "10.1021/ol4020392",

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journal = "Organic Letters",

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AU - Yoshikai, Naohiko

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N2 - O-Acetyl oximes derived from 2′-arylacetophenones undergo N-O bond cleavage/intramolecular N-arylation in the presence of a catalytic amount of iron(III) acetylacetonate in acetic acid. In combination with the conventional cross-coupling or directed C-H arylation, the reaction offers a convenient route to substituted phenanthridines.

AB - O-Acetyl oximes derived from 2′-arylacetophenones undergo N-O bond cleavage/intramolecular N-arylation in the presence of a catalytic amount of iron(III) acetylacetonate in acetic acid. In combination with the conventional cross-coupling or directed C-H arylation, the reaction offers a convenient route to substituted phenanthridines.

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Phenanthridine synthesis through iron-catalyzed intramolecular N-arylation of O-Acetyl oxime

Abstract

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