Phenotyping CYP3A4 and CYP3A5 in pediatrie populations by liquid chromatography/tandem mass spectrometry

Anita Tilve; Santosh Tilve; Naiyu Zheng; Ye Tian; Tomoyuki Oe; Peter C. Adamson; Jeffrey L. Galinkin; Ian A. Blair

Phenotyping CYP3A4 and CYP3A5 in pediatrie populations by liquid chromatography/tandem mass spectrometry

Anita Tilve, Santosh Tilve, Naiyu Zheng, Ye Tian, Tomoyuki Oe, Peter C. Adamson, Jeffrey L. Galinkin, Ian A. Blair

Research output: Contribution to conference › Paper › peer-review

Abstract

The CYP3A4 and CYP3A5 phenotype in pediatric populations for subsequent correlations with the patient's genotype was investigated. Reversed-phase chromatography was performed using a Waters Alliance 2690 HPLC system. The synthesis of stable isotope labeled midazolam was carried out in seven steps. This assay will be particularly useful for examining the functional consequences of the variant and wild type CYP3A4 genotype.

Original language	English
Pages	593-594
Number of pages	2
Publication status	Published - 2002
Externally published	Yes
Event	Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics - Orlando, FL, United States Duration: 2002 Jun 2 → 2002 Jun 6

Other

Other	Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics
Country/Territory	United States
City	Orlando, FL
Period	02/6/2 → 02/6/6

ASJC Scopus subject areas

Spectroscopy

Cite this

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title = "Phenotyping CYP3A4 and CYP3A5 in pediatrie populations by liquid chromatography/tandem mass spectrometry",

abstract = "The CYP3A4 and CYP3A5 phenotype in pediatric populations for subsequent correlations with the patient's genotype was investigated. Reversed-phase chromatography was performed using a Waters Alliance 2690 HPLC system. The synthesis of stable isotope labeled midazolam was carried out in seven steps. This assay will be particularly useful for examining the functional consequences of the variant and wild type CYP3A4 genotype.",

author = "Anita Tilve and Santosh Tilve and Naiyu Zheng and Ye Tian and Tomoyuki Oe and Adamson, {Peter C.} and Galinkin, {Jeffrey L.} and Blair, {Ian A.}",

year = "2002",

language = "English",

pages = "593--594",

note = "Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics ; Conference date: 02-06-2002 Through 06-06-2002",

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TY - CONF

T1 - Phenotyping CYP3A4 and CYP3A5 in pediatrie populations by liquid chromatography/tandem mass spectrometry

AU - Tilve, Anita

AU - Tilve, Santosh

AU - Zheng, Naiyu

AU - Tian, Ye

AU - Oe, Tomoyuki

AU - Adamson, Peter C.

AU - Galinkin, Jeffrey L.

AU - Blair, Ian A.

PY - 2002

Y1 - 2002

N2 - The CYP3A4 and CYP3A5 phenotype in pediatric populations for subsequent correlations with the patient's genotype was investigated. Reversed-phase chromatography was performed using a Waters Alliance 2690 HPLC system. The synthesis of stable isotope labeled midazolam was carried out in seven steps. This assay will be particularly useful for examining the functional consequences of the variant and wild type CYP3A4 genotype.

AB - The CYP3A4 and CYP3A5 phenotype in pediatric populations for subsequent correlations with the patient's genotype was investigated. Reversed-phase chromatography was performed using a Waters Alliance 2690 HPLC system. The synthesis of stable isotope labeled midazolam was carried out in seven steps. This assay will be particularly useful for examining the functional consequences of the variant and wild type CYP3A4 genotype.

UR - http://www.scopus.com/inward/record.url?scp=2442702007&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2442702007&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:2442702007

SP - 593

EP - 594

T2 - Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics

Y2 - 2 June 2002 through 6 June 2002

ER -

Phenotyping CYP3A4 and CYP3A5 in pediatrie populations by liquid chromatography/tandem mass spectrometry

Abstract

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ASJC Scopus subject areas

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