Background: The function of phosphatidylserinespecific phospholipase A1 (PS-PLA1), a phospholipase that acts specifically on phosphatidylserine and produces lyso-phosphatidylserine, a lysophospholipid mediator, has not been fully elucidated. We evaluated the role of PS-PLA1 in oncogenesis and metastasis of colorectal cancer (CRC). Materials and Methods: Specimens from 85 patients with CRC were immunostained with a monoclonal antibody against PS-PLA1. The correlation between PS-PLA1 expression and the clinicopathological variables was analyzed. Results: Tumor depth and hematogenous metastasis independently positively correlated with PS-PLA1 expression. High PS-PLA1 expression was associated with shorter disease-free survival, although it was not an independent predictive factor. Conclusion: PS-PLA1 expression in CRC is associated with tumor invasion and metastasis.
|Number of pages||6|
|Publication status||Published - 2015 Mar 1|
- Colorectal cancer
- Phosphati-dylserine-specific phospholipase A
- Tumor invasion