Phosphatidylserine-specific phospholipase A1 (PS-PLA1) expression in colorectal cancer correlates with tumor invasion and hematogenous metastasis

Yuuki Iida; Eiji Sunami; Hiroharu Yamashita; Masaya Hiyoshi; Soichiro Ishihara; Hironori Yamaguchi; Asuka Inoue; Kumiko Makide; Nelson H. Tsuno; Junken Aoki; Joji Kitayama; Toshiaki Watanabe

Phosphatidylserine-specific phospholipase A1 (PS-PLA1) expression in colorectal cancer correlates with tumor invasion and hematogenous metastasis

Yuuki Iida, Eiji Sunami, Hiroharu Yamashita, Masaya Hiyoshi, Soichiro Ishihara, Hironori Yamaguchi, Asuka Inoue, Kumiko Makide, Nelson H. Tsuno, Junken Aoki, Joji Kitayama, Toshiaki Watanabe

PHA - Life and Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Background: The function of phosphatidylserinespecific phospholipase A₁ (PS-PLA1), a phospholipase that acts specifically on phosphatidylserine and produces lyso-phosphatidylserine, a lysophospholipid mediator, has not been fully elucidated. We evaluated the role of PS-PLA₁ in oncogenesis and metastasis of colorectal cancer (CRC). Materials and Methods: Specimens from 85 patients with CRC were immunostained with a monoclonal antibody against PS-PLA₁. The correlation between PS-PLA₁ expression and the clinicopathological variables was analyzed. Results: Tumor depth and hematogenous metastasis independently positively correlated with PS-PLA₁ expression. High PS-PLA₁ expression was associated with shorter disease-free survival, although it was not an independent predictive factor. Conclusion: PS-PLA₁ expression in CRC is associated with tumor invasion and metastasis.

Original language	English
Pages (from-to)	1459-1464
Number of pages	6
Journal	Anticancer Research
Volume	35
Issue number	3
Publication status	Published - 2015 Mar 1

Keywords

Colorectal cancer
Immunohistochemistry
Metastasis
Phosphati-dylserine-specific phospholipase A
Tumor invasion

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@article{7293fe92dbb74a85aa3918bc22c8588c,

title = "Phosphatidylserine-specific phospholipase A1 (PS-PLA1) expression in colorectal cancer correlates with tumor invasion and hematogenous metastasis",

abstract = "Background: The function of phosphatidylserinespecific phospholipase A1 (PS-PLA1), a phospholipase that acts specifically on phosphatidylserine and produces lyso-phosphatidylserine, a lysophospholipid mediator, has not been fully elucidated. We evaluated the role of PS-PLA1 in oncogenesis and metastasis of colorectal cancer (CRC). Materials and Methods: Specimens from 85 patients with CRC were immunostained with a monoclonal antibody against PS-PLA1. The correlation between PS-PLA1 expression and the clinicopathological variables was analyzed. Results: Tumor depth and hematogenous metastasis independently positively correlated with PS-PLA1 expression. High PS-PLA1 expression was associated with shorter disease-free survival, although it was not an independent predictive factor. Conclusion: PS-PLA1 expression in CRC is associated with tumor invasion and metastasis.",

keywords = "Colorectal cancer, Immunohistochemistry, Metastasis, Phosphati-dylserine-specific phospholipase A, Tumor invasion",

author = "Yuuki Iida and Eiji Sunami and Hiroharu Yamashita and Masaya Hiyoshi and Soichiro Ishihara and Hironori Yamaguchi and Asuka Inoue and Kumiko Makide and Tsuno, {Nelson H.} and Junken Aoki and Joji Kitayama and Toshiaki Watanabe",

year = "2015",

month = mar,

day = "1",

language = "English",

volume = "35",

pages = "1459--1464",

journal = "Anticancer Research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

number = "3",

}

TY - JOUR

T1 - Phosphatidylserine-specific phospholipase A1 (PS-PLA1) expression in colorectal cancer correlates with tumor invasion and hematogenous metastasis

AU - Iida, Yuuki

AU - Sunami, Eiji

AU - Yamashita, Hiroharu

AU - Hiyoshi, Masaya

AU - Ishihara, Soichiro

AU - Yamaguchi, Hironori

AU - Inoue, Asuka

AU - Makide, Kumiko

AU - Tsuno, Nelson H.

AU - Aoki, Junken

AU - Kitayama, Joji

AU - Watanabe, Toshiaki

PY - 2015/3/1

Y1 - 2015/3/1

N2 - Background: The function of phosphatidylserinespecific phospholipase A1 (PS-PLA1), a phospholipase that acts specifically on phosphatidylserine and produces lyso-phosphatidylserine, a lysophospholipid mediator, has not been fully elucidated. We evaluated the role of PS-PLA1 in oncogenesis and metastasis of colorectal cancer (CRC). Materials and Methods: Specimens from 85 patients with CRC were immunostained with a monoclonal antibody against PS-PLA1. The correlation between PS-PLA1 expression and the clinicopathological variables was analyzed. Results: Tumor depth and hematogenous metastasis independently positively correlated with PS-PLA1 expression. High PS-PLA1 expression was associated with shorter disease-free survival, although it was not an independent predictive factor. Conclusion: PS-PLA1 expression in CRC is associated with tumor invasion and metastasis.

AB - Background: The function of phosphatidylserinespecific phospholipase A1 (PS-PLA1), a phospholipase that acts specifically on phosphatidylserine and produces lyso-phosphatidylserine, a lysophospholipid mediator, has not been fully elucidated. We evaluated the role of PS-PLA1 in oncogenesis and metastasis of colorectal cancer (CRC). Materials and Methods: Specimens from 85 patients with CRC were immunostained with a monoclonal antibody against PS-PLA1. The correlation between PS-PLA1 expression and the clinicopathological variables was analyzed. Results: Tumor depth and hematogenous metastasis independently positively correlated with PS-PLA1 expression. High PS-PLA1 expression was associated with shorter disease-free survival, although it was not an independent predictive factor. Conclusion: PS-PLA1 expression in CRC is associated with tumor invasion and metastasis.

KW - Colorectal cancer

KW - Immunohistochemistry

KW - Metastasis

KW - Phosphati-dylserine-specific phospholipase A

KW - Tumor invasion

UR - http://www.scopus.com/inward/record.url?scp=84924954732&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84924954732&partnerID=8YFLogxK

M3 - Article

C2 - 25750298

AN - SCOPUS:84924954732

SN - 0250-7005

VL - 35

SP - 1459

EP - 1464

JO - Anticancer Research

JF - Anticancer Research

IS - 3

ER -

Phosphatidylserine-specific phospholipase A1 (PS-PLA1) expression in colorectal cancer correlates with tumor invasion and hematogenous metastasis

Abstract

Keywords

UN SDGs

Other files and links

Fingerprint

Cite this