Photocytotoxicity of water-soluble fullerene derivatives

Kazuhiro Irie; Yoshimasa Nakamura; Hajime Ohigashi; Hidetoshi Tokuyama; Shigeru Yamago; Eiichi Nakamura

doi:10.1271/bbb.60.1359

Photocytotoxicity of water-soluble fullerene derivatives

Kazuhiro Irie, Yoshimasa Nakamura, Hajime Ohigashi, Hidetoshi Tokuyama, Shigeru Yamago, Eiichi Nakamura

PHA - Molecular Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

69 Citations (Scopus)

Abstract

New water-soluble fullerene carboxylic acids (1 and 2) derived from C₆₀ and C₇₀ fullerenes, respectively, were examined for photocytotoxicity toward Raji cells (B lymphocyte). These compounds did not show any photocytotoxic effect even at 50μ m, while pheophorbide a showed significant photocytotoxicity at 0.5 μ m. Therefore, fullerene derivatives derived from C₆₀ and C₇₀ would not be practical agents for photodynamic therapy.

Original language	English
Pages (from-to)	1359-1361
Number of pages	3
Journal	Bioscience, Biotechnology and Biochemistry
Volume	60
Issue number	8
DOIs	https://doi.org/10.1271/bbb.60.1359
Publication status	Published - 1996 Jan

Keywords

Fullerene
Pheophorbide a
Photocytotoxicity
Photodynamic therapy
Porphyrin

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title = "Photocytotoxicity of water-soluble fullerene derivatives",

abstract = "New water-soluble fullerene carboxylic acids (1 and 2) derived from C60 and C70 fullerenes, respectively, were examined for photocytotoxicity toward Raji cells (B lymphocyte). These compounds did not show any photocytotoxic effect even at 50μ m, while pheophorbide a showed significant photocytotoxicity at 0.5 μ m. Therefore, fullerene derivatives derived from C60 and C70 would not be practical agents for photodynamic therapy.",

keywords = "Fullerene, Pheophorbide a, Photocytotoxicity, Photodynamic therapy, Porphyrin",

author = "Kazuhiro Irie and Yoshimasa Nakamura and Hajime Ohigashi and Hidetoshi Tokuyama and Shigeru Yamago and Eiichi Nakamura",

note = "Funding Information: Acknowledgments. This work was supported in part by Grants-in-Aid for Scientific Research for the Encouragement of Young Scientists (No. 07760118) from the Ministry of Education, Science, and Culture of Japan (for K.I.), from Kurata Foundation (for S.Y.), and from Sumitomo Foundation (for E.N.). The authors thank Hoechst Japan for the generous supply of C 70'",

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doi = "10.1271/bbb.60.1359",

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T1 - Photocytotoxicity of water-soluble fullerene derivatives

AU - Irie, Kazuhiro

AU - Nakamura, Yoshimasa

AU - Ohigashi, Hajime

AU - Tokuyama, Hidetoshi

AU - Yamago, Shigeru

AU - Nakamura, Eiichi

N1 - Funding Information: Acknowledgments. This work was supported in part by Grants-in-Aid for Scientific Research for the Encouragement of Young Scientists (No. 07760118) from the Ministry of Education, Science, and Culture of Japan (for K.I.), from Kurata Foundation (for S.Y.), and from Sumitomo Foundation (for E.N.). The authors thank Hoechst Japan for the generous supply of C 70'

PY - 1996/1

Y1 - 1996/1

N2 - New water-soluble fullerene carboxylic acids (1 and 2) derived from C60 and C70 fullerenes, respectively, were examined for photocytotoxicity toward Raji cells (B lymphocyte). These compounds did not show any photocytotoxic effect even at 50μ m, while pheophorbide a showed significant photocytotoxicity at 0.5 μ m. Therefore, fullerene derivatives derived from C60 and C70 would not be practical agents for photodynamic therapy.

AB - New water-soluble fullerene carboxylic acids (1 and 2) derived from C60 and C70 fullerenes, respectively, were examined for photocytotoxicity toward Raji cells (B lymphocyte). These compounds did not show any photocytotoxic effect even at 50μ m, while pheophorbide a showed significant photocytotoxicity at 0.5 μ m. Therefore, fullerene derivatives derived from C60 and C70 would not be practical agents for photodynamic therapy.

KW - Fullerene

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KW - Photocytotoxicity

KW - Photodynamic therapy

KW - Porphyrin

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JO - Bioscience, Biotechnology and Biochemistry

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Photocytotoxicity of water-soluble fullerene derivatives

Abstract

Keywords

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