Photothermal ablation cancer therapy using homogeneous Cs xWO3 nanorods with broad near-infra-red absorption

Chongshen Guo, Shu Yin, Haijun Yu, Shaoqin Liu, Qiang Dong, Takehiro Goto, Zhiwen Zhang, Yaping Li, Tsugio Sato

Research output: Contribution to journalArticlepeer-review

79 Citations (Scopus)


Recently, photothermal ablation therapy (PTA) employing near-infrared radiation (NIR) has been extensively investigated as an emerging modality for cancer management. However, the clinical translation of this promising approach is limited by the lack of PTA agents with broad NIR absorption, low cost and high photothermal conversion efficiency. Herein, we have developed PEGylated homogeneous CsxWO3 nanorods (a mean size ∼69.3 nm × 12.8 nm) with broad photo-absorption (780-2500 nm) as a novel NIR absorbent for PTA treatment of human cancer. The prepared CsxWO 3 nanocrystals displayed strong near-infrared optical absorption with a high molar extinction coefficient (e.g. 4.8 × 1010 M -1 cm-1 at 980 nm), thus generated significant amounts of heat upon excitation with near-infrared light. The PTA study in two human carcinoma cell lines (i.e. A549 lung cancer cells and HeLa ovarian cancer cells) demonstrated that CsxWO3 nanorods can efficiently cause cell death via hyperthermia induced lysosome destruction, cytoskeleton protein degradation, DNA damage and thereafter cellular necrosis or apoptosis. Our study also confirmed the migration of healthy cells migrated from unirradiated areas to dead cell cycle, which is essential for tissue reconstruction and wound healing after photodestruction of tumor tissue. The prompted results reported in the current study imply the promising potential of CsxWO3 nanorods for application in PTA cancer therapy.

Original languageEnglish
Pages (from-to)6469-6478
Number of pages10
Issue number14
Publication statusPublished - 2013 Jul 21

ASJC Scopus subject areas

  • Materials Science(all)


Dive into the research topics of 'Photothermal ablation cancer therapy using homogeneous Cs xWO3 nanorods with broad near-infra-red absorption'. Together they form a unique fingerprint.

Cite this