The functional interleukin 2 (IL-2) receptors contain the β and γ chains which are necessary for the transduction of cell growth signals. Monoclonal antibodies specific for the β chain and γ chain coimmunoprecipitated JAK1 and 114-kDa JAK2 tyrosine kinases, respectively. Tyrosine phosphorylation of JAK1 and JAK2 was induced upon IL-2 stimulation, and IL-2 activated the JAK2 kinase. These results demonstrate that the JAK1 and JAK2 tyrosine kinases are physically associated with the β chain and γ chain, respectively, and suggest that regulation of the kinases may be linked to IL-2-induced signal transduction.
|Number of pages||5|
|Journal||Proceedings of the National Academy of Sciences of the United States of America|
|Publication status||Published - 1994 Jul 19|