Supplementation to an AIN93G-based diet of tocotrienol (T3) for 13 weeks administered to Fischer 344/ slc rats showed a safety profile with no side effects. Dosedependent T3 levels were detected in many tissues. Under the present experimental conditions, a continuous intake of the T3 concentrate would be safe in the rats as long as the T3 content was less than 0.20% of the dietary intake.
- Large dose
- Tissue distribution