@article{3657c13eb258407caa46e67c67b9b129,
title = "Physiological effects and tissue distribution from large doses of tocotrienol in rats",
abstract = "Supplementation to an AIN93G-based diet of tocotrienol (T3) for 13 weeks administered to Fischer 344/ slc rats showed a safety profile with no side effects. Dosedependent T3 levels were detected in many tissues. Under the present experimental conditions, a continuous intake of the T3 concentrate would be safe in the rats as long as the T3 content was less than 0.20% of the dietary intake.",
keywords = "Large dose, Rat, Tissue distribution, Tocopherol, Tocotrienol",
author = "Akira Shibata and Kiyotaka Nakagawa and Hitoshi Shirakawa and Teiko Kobayashi and Yuki Kawakami and Rie Takashima and Ai Ohashi and Shoko Sato and Yusuke Ohsaki and Fumiko Kimura and Toshiyuki Kimura and Tsuyoshi Tsuduki and Michio Komai and Teruo Miyazawa",
note = "Funding Information: This work was supported by grant-aid from the Bio-oriented Technology Research Advancement Center of the National Agricultural and Biological Research Organization of Japan. This work was also partly supported by Kakenhi (S) (20228002, to T. M.) of JSPS of Japan.",
year = "2012",
doi = "10.1271/bbb.120387",
language = "English",
volume = "76",
pages = "1805--1808",
journal = "Bioscience, Biotechnology and Biochemistry",
issn = "0916-8451",
publisher = "Oxford University Press",
number = "9",
}