Pico calorimeter for detection of heat produced in an individual brown fat cell

Naoki Inomata; Masaya Toda; Masaaki Sato; Akihiko Ishijima; Takahito Ono

doi:10.1063/1.3701720

Pico calorimeter for detection of heat produced in an individual brown fat cell

Naoki Inomata, Masaya Toda, Masaaki Sato, Akihiko Ishijima, Takahito Ono

Tohoku University

Research output: Contribution to journal › Article › peer-review

78 Citations (Scopus)

Abstract

A pico calorimeter with a highly sensitive sensor for detecting heat from a biological cell is developed and evaluated, and also the heat detection of a single brown fat cell has been demonstrated. The measurement principle relies on resonant frequency tracking of a resonator in temperature variation due to the heat from the sample; the resonator is placed in vacuum, and heat is conducted from the sample in the microfluidic channel via a heat guide. This configuration can prevent heat loss from the resonator to the surroundings and damping in water. The heat resolution of the fabricated sensor is 5.2 pJ. Heat emissions from single cells are detected as pulsed or continuous in the absence and presence of stimulation, respectively.

Original language	English
Article number	154104
Journal	Applied Physics Letters
Volume	100
Issue number	15
DOIs	https://doi.org/10.1063/1.3701720
Publication status	Published - 2012 Apr 9

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10.1063/1.3701720

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title = "Pico calorimeter for detection of heat produced in an individual brown fat cell",

abstract = "A pico calorimeter with a highly sensitive sensor for detecting heat from a biological cell is developed and evaluated, and also the heat detection of a single brown fat cell has been demonstrated. The measurement principle relies on resonant frequency tracking of a resonator in temperature variation due to the heat from the sample; the resonator is placed in vacuum, and heat is conducted from the sample in the microfluidic channel via a heat guide. This configuration can prevent heat loss from the resonator to the surroundings and damping in water. The heat resolution of the fabricated sensor is 5.2 pJ. Heat emissions from single cells are detected as pulsed or continuous in the absence and presence of stimulation, respectively.",

author = "Naoki Inomata and Masaya Toda and Masaaki Sato and Akihiko Ishijima and Takahito Ono",

note = "Funding Information: This research was supported in part by the Core Research for Evolutional Science and Technology (CREST) and in part by the Japan Science and Technology Agency (JST), a Grant-in Aid for Scientific Research from the Japanese Ministry of Education, Culture, Sports, Science and Technology of Japan, and Research Fellowships of the Japan Society for the Promotion of Science for Young Scientists. Part of this work is performed in Microsystem Integration Center (μSIC), Tohoku University.",

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AU - Sato, Masaaki

AU - Ishijima, Akihiko

AU - Ono, Takahito

N1 - Funding Information: This research was supported in part by the Core Research for Evolutional Science and Technology (CREST) and in part by the Japan Science and Technology Agency (JST), a Grant-in Aid for Scientific Research from the Japanese Ministry of Education, Culture, Sports, Science and Technology of Japan, and Research Fellowships of the Japan Society for the Promotion of Science for Young Scientists. Part of this work is performed in Microsystem Integration Center (μSIC), Tohoku University.

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AB - A pico calorimeter with a highly sensitive sensor for detecting heat from a biological cell is developed and evaluated, and also the heat detection of a single brown fat cell has been demonstrated. The measurement principle relies on resonant frequency tracking of a resonator in temperature variation due to the heat from the sample; the resonator is placed in vacuum, and heat is conducted from the sample in the microfluidic channel via a heat guide. This configuration can prevent heat loss from the resonator to the surroundings and damping in water. The heat resolution of the fabricated sensor is 5.2 pJ. Heat emissions from single cells are detected as pulsed or continuous in the absence and presence of stimulation, respectively.

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Pico calorimeter for detection of heat produced in an individual brown fat cell

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