TY - GEN
T1 - Pinpoint keV/MeV x-ray sources for x-ray drug delivery system
AU - Uesaka, M.
AU - Mizuno, K.
AU - Sakumi, A.
AU - Meiling, J.
AU - Yusa, Noritaka
AU - Takahashi, H.
AU - Nishiyama, N.
AU - Kataoka, K.
AU - Nakagawa, K.
PY - 2007/12/1
Y1 - 2007/12/1
N2 - X-ray Drug Delivery System (DDS) is the most advanced radiation therapy coming after IMRT (Intensity Modulated Radiation Therapy) and IGRT (Image Guided). DDS uses advanced nano-scaled polymers which contain and deliver drug or contrast agent to cancers without side effects. Several X-ray DDS poses high-Z atoms like Pt and Au to absorb X-rays effectively and used as contrast agent for inspection. Moreover, they have radiation enhancement effect by emission of Auger electron and successive characteristic X-rays. The enhancement factor of Pt and Au is more than five. This can be used for therapy. This new modality must be very important for inspection and therapy of deep cancers. We are making use of our Compton scattering monochromatic keV X-ray source and MeV linac aspinpoint keV/MeV X-ray sources for the purpose. Physical analysis and evaluation of the contrast efficiency and radiation enhancement of the X-ray DDS are under way. Furthermore, a new compact X-band linac with a multi-beam klystron for a pinpoint X-ray source is proposed and designed. Updated research status and result are presented.
AB - X-ray Drug Delivery System (DDS) is the most advanced radiation therapy coming after IMRT (Intensity Modulated Radiation Therapy) and IGRT (Image Guided). DDS uses advanced nano-scaled polymers which contain and deliver drug or contrast agent to cancers without side effects. Several X-ray DDS poses high-Z atoms like Pt and Au to absorb X-rays effectively and used as contrast agent for inspection. Moreover, they have radiation enhancement effect by emission of Auger electron and successive characteristic X-rays. The enhancement factor of Pt and Au is more than five. This can be used for therapy. This new modality must be very important for inspection and therapy of deep cancers. We are making use of our Compton scattering monochromatic keV X-ray source and MeV linac aspinpoint keV/MeV X-ray sources for the purpose. Physical analysis and evaluation of the contrast efficiency and radiation enhancement of the X-ray DDS are under way. Furthermore, a new compact X-band linac with a multi-beam klystron for a pinpoint X-ray source is proposed and designed. Updated research status and result are presented.
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U2 - 10.1109/PAC.2007.4440578
DO - 10.1109/PAC.2007.4440578
M3 - Conference contribution
AN - SCOPUS:51349155623
SN - 1424409179
SN - 9781424409174
T3 - Proceedings of the IEEE Particle Accelerator Conference
SP - 2793
EP - 2795
BT - Proceedings of the IEEE Particle Accelerator Conference, PAC07
T2 - IEEE Particle Accelerator Conference, PAC07
Y2 - 25 June 2007 through 29 June 2007
ER -
