Plasma cell leukemia maintaining complete remission by syngeneic stem cell transplantation combined with low-dose thalidomide maintenance therapy

Masahiro Abe; Hisayuki Yokoyama; Yasuo Tohmiya; Yoko Okitsu; Hiroto Ohguchi; Katsura Kohata; Joji Yamamoto; Yasushi Onishi; Kenichi Ishizawa; Junichi Kameoka; Hideo Harigae

doi:10.2169/internalmedicine.48.2389

Plasma cell leukemia maintaining complete remission by syngeneic stem cell transplantation combined with low-dose thalidomide maintenance therapy

Masahiro Abe, Hisayuki Yokoyama, Yasuo Tohmiya, Yoko Okitsu, Hiroto Ohguchi, Katsura Kohata, Joji Yamamoto, Yasushi Onishi, Kenichi Ishizawa, Junichi Kameoka, Hideo Harigae

Tohoku University

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Plasma cell leukemia (PCL) is a rare variant of multiple myeloma, which is very aggressive and resistant to chemotherapy. We report a case of PCL successfully treated with syngeneic peripheral blood stem cell transplantation followed by low-dose thalidomide. As of March 2009, the patient has maintained CR for 39 months posttransplant. The clinical course of the present case suggests that autologous stem cell transplantation using a graft with reduced contamination of malignant cells followed by low-dose thalidomide maintenance therapy may improve the PCL treatment outcome.

Original language	English
Pages (from-to)	1833-1835
Number of pages	3
Journal	Internal Medicine
Volume	48
Issue number	20
DOIs	https://doi.org/10.2169/internalmedicine.48.2389
Publication status	Published - 2009

Keywords

Low-dose thalidomide
Plasma cell leukemia
Syngeneic stem cell transplantation

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Abe, M., Yokoyama, H., Tohmiya, Y., Okitsu, Y., Ohguchi, H., Kohata, K., Yamamoto, J., Onishi, Y., Ishizawa, K., Kameoka, J., & Harigae, H. (2009). Plasma cell leukemia maintaining complete remission by syngeneic stem cell transplantation combined with low-dose thalidomide maintenance therapy. Internal Medicine, 48(20), 1833-1835. https://doi.org/10.2169/internalmedicine.48.2389

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title = "Plasma cell leukemia maintaining complete remission by syngeneic stem cell transplantation combined with low-dose thalidomide maintenance therapy",

abstract = "Plasma cell leukemia (PCL) is a rare variant of multiple myeloma, which is very aggressive and resistant to chemotherapy. We report a case of PCL successfully treated with syngeneic peripheral blood stem cell transplantation followed by low-dose thalidomide. As of March 2009, the patient has maintained CR for 39 months posttransplant. The clinical course of the present case suggests that autologous stem cell transplantation using a graft with reduced contamination of malignant cells followed by low-dose thalidomide maintenance therapy may improve the PCL treatment outcome.",

keywords = "Low-dose thalidomide, Plasma cell leukemia, Syngeneic stem cell transplantation",

author = "Masahiro Abe and Hisayuki Yokoyama and Yasuo Tohmiya and Yoko Okitsu and Hiroto Ohguchi and Katsura Kohata and Joji Yamamoto and Yasushi Onishi and Kenichi Ishizawa and Junichi Kameoka and Hideo Harigae",

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doi = "10.2169/internalmedicine.48.2389",

language = "English",

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Abe, M, Yokoyama, H, Tohmiya, Y, Okitsu, Y, Ohguchi, H, Kohata, K, Yamamoto, J, Onishi, Y, Ishizawa, K, Kameoka, J & Harigae, H 2009, 'Plasma cell leukemia maintaining complete remission by syngeneic stem cell transplantation combined with low-dose thalidomide maintenance therapy', Internal Medicine, vol. 48, no. 20, pp. 1833-1835. https://doi.org/10.2169/internalmedicine.48.2389

TY - JOUR

T1 - Plasma cell leukemia maintaining complete remission by syngeneic stem cell transplantation combined with low-dose thalidomide maintenance therapy

AU - Abe, Masahiro

AU - Yokoyama, Hisayuki

AU - Tohmiya, Yasuo

AU - Okitsu, Yoko

AU - Ohguchi, Hiroto

AU - Kohata, Katsura

AU - Yamamoto, Joji

AU - Onishi, Yasushi

AU - Ishizawa, Kenichi

AU - Kameoka, Junichi

AU - Harigae, Hideo

PY - 2009

Y1 - 2009

N2 - Plasma cell leukemia (PCL) is a rare variant of multiple myeloma, which is very aggressive and resistant to chemotherapy. We report a case of PCL successfully treated with syngeneic peripheral blood stem cell transplantation followed by low-dose thalidomide. As of March 2009, the patient has maintained CR for 39 months posttransplant. The clinical course of the present case suggests that autologous stem cell transplantation using a graft with reduced contamination of malignant cells followed by low-dose thalidomide maintenance therapy may improve the PCL treatment outcome.

AB - Plasma cell leukemia (PCL) is a rare variant of multiple myeloma, which is very aggressive and resistant to chemotherapy. We report a case of PCL successfully treated with syngeneic peripheral blood stem cell transplantation followed by low-dose thalidomide. As of March 2009, the patient has maintained CR for 39 months posttransplant. The clinical course of the present case suggests that autologous stem cell transplantation using a graft with reduced contamination of malignant cells followed by low-dose thalidomide maintenance therapy may improve the PCL treatment outcome.

KW - Low-dose thalidomide

KW - Plasma cell leukemia

KW - Syngeneic stem cell transplantation

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DO - 10.2169/internalmedicine.48.2389

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AN - SCOPUS:71049191931

SN - 0918-2918

VL - 48

SP - 1833

EP - 1835

JO - Internal Medicine

JF - Internal Medicine

IS - 20

ER -

Plasma cell leukemia maintaining complete remission by syngeneic stem cell transplantation combined with low-dose thalidomide maintenance therapy

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Keywords

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