TY - JOUR
T1 - Plasma plasminogen activator inhibitor-1, tissue plasminogen activator and serum lipoprotein(a) after reperfusion therapy in acute myocardial infarction
T2 - Comparison between sequential and direct percutaneous transluminal coronary angioplasty
AU - Hara, Masahide
AU - Ito, Kenichiro
AU - Nawata, Tomoko
AU - Tsunematsu, Yoshihiro
AU - Shimoyama, Nobuo
AU - Maeda, Toshihiro
AU - Sato, Yasufumi
AU - Saikawa, Tetsunori
AU - He Sakata, Tosh
PY - 1995
Y1 - 1995
N2 - To determine which reperfusion therapy for acute myocardial infarction (AMI) is advantageous to avoid subsequent thrombotic coronary occlusion, 8 patients with AMI were studied. Four of them (group S) underwent sequential PTCA following unsuccessful intracoronary thrombolysis and the others (group D) direct PTCA. Serial changes in plasma plasminogen activator inhibitor-1 (PAI-1), plasma tissue plasminogen activator (t-PA) antigen and serum lipoprotein(a) levels were compared between the two groups. In group S, plasma PAI-1 levels showed no significant serial change after PTCA. However, in group D, plasma PAI-1 levels increased significantly 4-24 h after PTCA. We suggest that more attention should be focused on the prevention of thrombotic coronary closure as well as mechanical abrupt occlusion after direct PTCA.
AB - To determine which reperfusion therapy for acute myocardial infarction (AMI) is advantageous to avoid subsequent thrombotic coronary occlusion, 8 patients with AMI were studied. Four of them (group S) underwent sequential PTCA following unsuccessful intracoronary thrombolysis and the others (group D) direct PTCA. Serial changes in plasma plasminogen activator inhibitor-1 (PAI-1), plasma tissue plasminogen activator (t-PA) antigen and serum lipoprotein(a) levels were compared between the two groups. In group S, plasma PAI-1 levels showed no significant serial change after PTCA. However, in group D, plasma PAI-1 levels increased significantly 4-24 h after PTCA. We suggest that more attention should be focused on the prevention of thrombotic coronary closure as well as mechanical abrupt occlusion after direct PTCA.
KW - Acute myocardial infarction
KW - Lipoprotein(a)
KW - Percutaneous transluminal coronary angioplasty
KW - Plasminogen activator inhibitor-1
KW - Tissue plasminogen activator
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U2 - 10.1159/000176911
DO - 10.1159/000176911
M3 - Article
C2 - 7585744
AN - SCOPUS:0029088237
SN - 0008-6312
VL - 86
SP - 407
EP - 410
JO - Cardiology
JF - Cardiology
IS - 5
ER -