Plasma soluble (Pro)renin receptor is independent of plasma renin, prorenin, and aldosterone concentrations but is affected by ethnicity

Geneviève Nguyen, Anne Blanchard, Emmanuel Curis, Damien Bergerot, Yann Chambon, Takuo Hirose, Aurore Caumont-Prim, Sylvie Brailly Tabard, Stéphanie Baron, Michael Frank, Kazuhito Totsune, Michel Azizi

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)


A soluble (pro)renin receptor (sPRR) circulates in plasma and is able to bind renin and prorenin. It is not known whether plasma sPRR concentrations vary with the activity of the renin-angiotensin system. We measured plasma sPRR, renin, prorenin, and aldosterone concentrations in 121 white and 9 black healthy subjects, 40 patients with diabetes mellitus, 41 hypertensive patients with or without renin-angiotensin system blockers, 9 patients with primary aldosteronism, and 10 patients with Gitelman syndrome. Median physiological plasma sPRR concentration was 23.5 ng/mL (interquartile range, 20.9-26.5) under usual uncontrolled sodium diet. sPRR concentration in healthy subjects, unlike renin and prorenin, did not display circadian variation or dependence on age, sex, posture, or hormonal status. sPRR concentrations were ≈25% lower in black than in white subjects, whereas renin concentrations were ≈40% lower. Patients with diabetes mellitus (average renin-high prorenin levels) and with hypertension only (average renin-average prorenin levels) had sPRR concentrations similar to healthy subjects. Renin-angiotensin system blockade was associated with increase of sPRR concentration by ≈12%. sPRR in patients with primary aldosteronism (low renin-low prorenin) and Gitelman syndrome (high renin-high prorenin) were similar and ≈10% higher than in healthy subjects. There was no correlation between sPRR and renin or prorenin. In conclusion, our results show that plasma sPRR concentrations are dependent on ethnicity and independent of renin, prorenin, and aldosterone concentrations in healthy subjects and in patients with contrasted degrees of renin-angiotensin system activity.

Original languageEnglish
Pages (from-to)297-302
Number of pages6
Issue number2
Publication statusPublished - 2014 Feb


  • diabetes mellitus
  • essential
  • ethnology
  • hyperaldosteronism
  • hypertension


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