Plasmid-mediated PER-1 extended-spectrum betalactamase in Providencia retgeri from Bulgaria

S. Sabtcheva, T. Kantardjiev, E. Georgieva, S. Panaiotov, M. Kaku

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


A multiresistant Providencia rettgeri strain was isolated from the urine of a 38-year-old female cancer patient during an episode of febrile neutropenia that followed a course of postoperative adjuvant chemotherapy. The strain was resistant to beta-lactams (except cephamycins and carbapenems), aminoglycosides, fluoroquinolones, chloramphenicol, tetracycline, trimethoprim and sulfonamides. Clavulanic acid restored activity of oxyiminocephalosporins, suggesting the production of an extended-spectrum beta-lactamase (ESBL). PCR and sequencing with primers specific for known ESBL genes identified blaPER-1. The PER-1 determinant was transferable by conjugation and cotransferred with blaTEM-1 (ampicillin resistance), aac(6')-Ib ( amikacintobramycin-kanamycin resistance), gentamicin, chloramphenicol, trimethoprim and sulfonamide resistance determinants. Plasmid-mediated quinolone resistance determinants (qnr and aac(6')-Ib-cr) were not detected. This is the first description of plasmid-mediated PER-1 enzyme in Enterobacteriaceae in Bulgaria. Since PER-1-positive Gram-negative pathogens have been increasingly isolated in Turkey and Europe, and given the potential for further dissemination, nationwide early recognition and rapid identification of PER-1-producing bacteria should be considered to avoid further spread of this resistance determinant.

Original languageEnglish
Pages (from-to)29-30
Number of pages2
JournalProblems of Infectious and Parasitic Diseases
Issue number2
Publication statusPublished - 2008


  • Extended-spectrum beta-lactamase
  • PER-1
  • Providencia rettgeri

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Infectious Diseases


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