PMab-247 Detects Bear Podoplanin in Immunohistochemical Analysis

Junko Takei, Yoshikazu Furusawa, Shinji Yamada, Takuro Nakamura, Yusuke Sayama, Masato Sano, Satoru Konnai, Atsushi Kobayashi, Hiroyuki Harada, Mika K. Kaneko, Yukinari Kato

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14 Citations (Scopus)


Podoplanin (PDPN) is utilized as a specific marker of type I alveolar cells of lung and lymphatic endothelial cells of every tissue. Therefore, sensitive and specific monoclonal antibodies detecting PDPN are necessary for immunohistochemical analyses, especially using formalin-fixed paraffin-embedded tissues. Recently, we developed an anti-bear PDPN (bPDPN) mAb, PMab-247, which is useful for Western blot, flow cytometry, and immunohistochemical analyses. In this study, immunohistochemical analyses showed that PMab-247 strongly detected bPDPN, which is expressed in type I alveolar cells and lymphatic endothelial cells of bear lung and podocytes of bear kidney. These findings suggest that PMab-247 could be useful for pathophysiological analyses using immunohistochemistry.

Original languageEnglish
Pages (from-to)171-174
Number of pages4
JournalMonoclonal Antibodies in Immunodiagnosis and Immunotherapy
Issue number4
Publication statusPublished - 2019 Aug


  • PDPN
  • PMab-247
  • bear podoplanin
  • lymphatic endothelial cells
  • type I alveolar cells


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